Hypoxia-inducible factor 1 (HIF-1) is a new therapeutic target in JAK2V617F-positive myeloproliferative neoplasms

Julian Baumeister, Nicolas Chatain, Annika Hubrich, +14

Leukemia

Hematological MalignancyNew Therapeutic TargetHypoxia (Medicine)ImmunologyHematology +6

Calreticulin-mutant proteins induce megakaryocytic signaling to transform hematopoietic cells and undergo accelerated degradation and Golgi-mediated secretion

Lijuan Han, Claudia Schubert, Johanna Köhler, +5

Journal of Hematology & Oncology

Tyrosine kinase inhibitor–induced defects in DNA repair sensitize FLT3(ITD)-positive leukemia cells to PARP1 inhibitors

Silvia Maifrede, Margaret Nieborowska-Skorska, Katherine Sullivan-Reed, +24

Blood

JAK2V617F but not CALR mutations confer increased molecular responses to interferon-α via JAK1/STAT1 activation

Julia Czech, Sabrina Cordua, Barbora Weinbergerová, +23

Leukemia

Transcriptional RegulationIncreased Molecular ResponsesSignal TransductionSignaling PathwayMolecular Regulation +11

Intercellular trafficking of the nuclear oncoprotein DEK

Anjan K. Saha, Ferdinand Kappes, Amruta Mundade, +10

Proceedings of the National Academy of Sciences

Molecular BiologyCell CycleDek InternalizationGlobal Heterochromatin IntegrityCellular Physiology +15

Splice Variants of the Dual Specificity Tyrosine Phosphorylation-regulated Kinase 4 (DYRK4) Differ in Their Subcellular Localization and Catalytic Activity

Chrisovalantis Papadopoulos, Krisztina Arató, Eva Lilienthal, +6

Journal of Biological Chemistry

Molecular RegulationMolecular BiologyCell DifferentiationTranscriptional RegulationSignaling Pathway +22

Stem cell persistence in CML is mediated by extrinsically activated JAK1-STAT3 signaling

Maja Kim Kuepper, Marlena Bütow, Oliver Herrmann, +11

Leukemia

Signal TransductionDevelopmental BiologySignaling PathwayCell RegulationMedicine +7

Therapeutic Cancer Vaccination With a Peptide Derived From the Calreticulin Exon 9 Mutations Induces Strong Cellular Immune Responses in Patients With CALR-Mutant Chronic Myeloproliferative Neoplasms

Jacob Handlos Grauslund, Morten Orebo Holmström, Nicolai Grønne Dahlager Jørgensen, +19

Frontiers in Oncology

Chiral Analogues of PFI-1 as BET Inhibitors and Their Functional Role in Myeloid Malignancies

Bianca Altenburg, Marcus Frings, Jan‐Hendrik Schöbel, +7

ACS Medicinal Chemistry Letters

Drug TargetBet InhibitorsChiral AnaloguesTumor BiologyMyeloid Neoplasia +15

Src family kinases mediate cytoplasmic retention of activated STAT5 in BCR–ABL-positive cells

Nicolas Chatain, Patrick Ziegler, Dirk Fahrenkamp, +4

Oncogene

Signal TransductionSignaling PathwayActivated Stat5Cell RegulationReceptor Tyrosine Kinase +8