Context-Dependent and Disease-Specific Diversity in Protein Interactions within Stress Granules

Sebastian Markmiller, Sahar Soltanieh, Kari L. Server, +14

Cell

Protein FunctionFunctional GenomicsInteractomicsProtein FoldingStress +9

Targeted degradation of sense and antisense <i>C9orf72</i> RNA foci as therapy for ALS and frontotemporal degeneration

Clotilde Lagier‐Tourenne, Michael W. Baughn, Frank Rigo, +27

Proceedings of the National Academy of Sciences

Neurodegenerative DiseasesAmyotrophic Lateral SclerosisSporadic AlsChromosome 9Genetics +11

Programmable RNA Tracking in Live Cells with CRISPR/Cas9

David A. Nelles, Mark Y. Fang, Mitchell R. O’Connell, +4

Cell

Off-target EffectProgrammable Rna TrackingGene EditingGenome EditingGene Expression +3

Small-Molecule Modulation of TDP-43 Recruitment to Stress Granules Prevents Persistent TDP-43 Accumulation in ALS/FTD

Mark Y. Fang, Sebastian Markmiller, Anthony Q. Vu, +14

Neuron

Reductive StressTdp-43 RecruitmentNeurodegenerative DiseasesAmyotrophic Lateral SclerosisSignal Transduction +8

Elimination of Toxic Microsatellite Repeat Expansion RNA by RNA-Targeting Cas9

Ranjan Batra, David A. Nelles, Elaine Pirie, +13

Cell

GeneticsGenetic EngineeringMolecular BiologyMolecular GeneticsGene Editing +5

Large-scale tethered function assays identify factors that regulate mRNA stability and translation

En‐Ching Luo, Jason L. Nathanson, Frederick E. Tan, +12

Nature Structural & Molecular Biology

Protein ExpressionTranslational BiologyNatural SciencesMrna StabilityRna Biology +7

Biallelic mutations in the 3′ exonuclease TOE1 cause pontocerebellar hypoplasia and uncover a role in snRNA processing

Rea M. Lardelli, Ashleigh E. Schaffer, Veerle Rc Eggens, +54

Nature Genetics

BiologyBiallelic MutationsMendelian DisorderGenetic DisorderGenetics +3

Autophagy Induction Is a Tor- and Tp53-Independent Cell Survival Response in a Zebrafish Model of Disrupted Ribosome Biogenesis

Yeliz Boglev, Andrew P. Badrock, Andrew J. Trotter, +20

PLoS Genetics

Minor class splicing shapes the zebrafish transcriptome during development

Sebastian Markmiller, Nicole Cloonan, Rea M. Lardelli, +13

Proceedings of the National Academy of Sciences

Rna ProcessingDevelopmental BiologyGeneticsMinor ClassRna Splicing +11

Huntington’s disease mice and human brain tissue exhibit increased G3BP1 granules and TDP43 mislocalization

Isabella Sanchez, Thai B. Nguyen, Whitney England, +15

Journal of Clinical Investigation