Endogenous Glucocorticoid Signaling Regulates CD8+ T Cell Differentiation and Development of Dysfunction in the Tumor Microenvironment

Nandini Acharya, Asaf Madi, Huiyuan Zhang, +17

Immunity

Cancer ImmunosurveillanceLymphocyte DevelopmentT-regulatory CellImmunologyCell Biology +5

miR-221/222 Target the DNA Methyltransferase MGMT in Glioma Cells

Cristina Quintavalle, Davide Mangani, Giuseppina Roscigno, +9

PLoS ONE

Charting the cellular biogeography in colitis reveals fibroblast trajectories and coordinated spatial remodeling

Paolo Cadinu, Kisha N. Sivanathan, Aditya Misra, +18

Cell

InflammationMucosal ImmunologyMedicineGastroenterologyPathology +6

Tumor immunogenicity dictates reliance on TCF1 in CD8+ T cells for response to immunotherapy

Giulia Escobar, Katherine Tooley, Joan Pagès Oliveras, +13

Cancer Cell

Tumor ImmunologyTumor ImmunogenicityCancer ImmunosurveillanceImmunologyTumor Immunity +9

PD-L1+ and XCR1+ dendritic cells are region-specific regulators of gut homeostasis

Thaís G. Moreira, Davide Mangani, Laura M. Cox, +16

Nature Communications

CLA-supplemented diet accelerates experimental colorectal cancer by inducing TGF-β-producing macrophages and T cells

Thaís G. Moreira, Laila Sampaio Horta, Ana Cristina Gomes-Santos, +14

Mucosal Immunology

Limited role for transforming growth factor–β pathway activation-mediated escape from VEGF inhibition in murine glioma models

Davide Mangani, Michael Weller, Emad Seyed Sadr, +6

Neuro-Oncology

A metabolic switch orchestrated by IL-18 and the cyclic dinucleotide cGAMP programs intestinal tolerance

R. Tyler Mertens, Aditya Misra, Peng Xiao, +15

Immunity

Autoimmune DiseaseMucosal ImmunologyMedicineImmunologyGastroenterology +6

Transcription factor TCF1 binds to RORγt and orchestrates a regulatory network that determines homeostatic Th17 cell state

Davide Mangani, Ayshwarya Subramanian, Linglin Huang, +14

Immunity

Transcriptional RegulationTranscription Factor Tcf1Signal TransductionCell RegulationSignaling Pathway +11

Nasal administration of anti-CD3 mAb (Foralumab) downregulates <i>NKG7</i> and increases <i>TGFB1</i> and <i>GIMAP7</i> expression in T cells in subjects with COVID-19

Thaís G. Moreira, Christian Gauthier, Liam Murphy, +11

Proceedings of the National Academy of Sciences