Colin Osborne

Amino Acid Substitution in<i>Trichophyton rubrum</i>Squalene Epoxidase Associated with Resistance to Terbinafine

Colin Osborne, Ingrid Leitner, Bertrand Favre et al. · Antimicrobial Agents and Chemotherapy · 2005 · 146 citations · Full text

Terbinafine Resistance, Genetics, Molecular Biology +20

Discovery of LFF571: An Investigational Agent for <i>Clostridium difficile</i> Infection

Matthew J. LaMarche, Jennifer A. Leeds, Adam Amaral et al. · Journal of Medicinal Chemistry · 2012 · 116 citations

Bioorganic Chemistry, Bacteriophage, Investigational Agent +20

Identification of broad-spectrum antiviral compounds and assessment of the druggability of their target for efficacy against respiratory syncytial virus (RSV)

Aurelio Bonavia, Michael Franti, Erin P. Keaney et al. · Proceedings of the National Academy of Sciences · 2011 · 94 citations

Novel Therapeutic Interventions, Medicinal Chemistry, Respiratory Syncytial Virus +15

Biological, Biochemical, and Molecular Characterization of a New Clinical <i>Trichophyton rubrum</i> Isolate Resistant to Terbinafine

Colin Osborne, Ingrid Leitner, Bettina Hofbauer et al. · Antimicrobial Agents and Chemotherapy · 2006 · 88 citations · Full text

NITD-688, a pan-serotype inhibitor of the dengue virus NS4B protein, shows favorable pharmacokinetics and efficacy in preclinical animal models

Stephanie Moquin, Oliver Simon, Ratna Karuna et al. · Science Translational Medicine · 2021 · 81 citations

Pan-serotype Inhibitor, Dengue Virus, Immunology +16