Biological, Biochemical, and Molecular Characterization of a New Clinical <i>Trichophyton rubrum</i> Isolate Resistant to Terbinafine

Abstract

We have characterized a new clinical strain of Trichophyton rubrum highly resistant to terbinafine but exhibiting normal susceptibility to drugs with other mechanisms of action. Resistance to terbinafine in this strain is caused by a missense mutation in the squalene epoxidase gene leading to the amino acid substitution F397L.