LRRK2 mediates tubulation and vesicle sorting from lysosomes

Luis Bonet‐Ponce, Alexandra Beilina, Chad D. Williamson, +9

Science Advances

Dysregulation of glucose metabolism is an early event in sporadic Parkinson's disease

Laura B. Dunn, G Allen, Adamantios Mamais, +9

Neurobiology of Aging

Inhibition of LRRK2 kinase activity stimulates macroautophagy

Claudia Manzoni, Adamantios Mamais, Sybille Dihanich, +7

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

InflammationCell AutophagyMitophagySignal TransductionSignaling Pathway +12

Hexokinases link DJ-1 to the PINK1/parkin pathway

David N. Hauser, Adamantios Mamais, Melissa M. Conti, +14

Molecular Neurodegeneration

Phosphorylation of LRRK2 by casein kinase 1α regulates trans-Golgi clustering via differential interaction with ARHGEF7

Ruth Chia, Sara Haddock, Alexandra Beilina, +7

Nature Communications

Signal TransductionSignaling PathwayMolecular PathwayMedicineNatural Sciences +9

Pathogenic Parkinson’s disease mutations across the functional domains of LRRK2 alter the autophagic/lysosomal response to starvation

Claudia Manzoni, Adamantios Mamais, Sybille Dihanich, +13

Biochemical and Biophysical Research Communications

mTOR independent regulation of macroautophagy by Leucine Rich Repeat Kinase 2 via Beclin-1

Claudia Manzoni, Adamantios Mamais, Dorien A. Roosen, +8

Scientific Reports

Detection of endogenous S1292 LRRK2 autophosphorylation in mouse tissue as a readout for kinase activity

Jillian H. Kluss, Melissa M. Conti, Alice Kaganovich, +4

npj Parkinson s Disease

The Parkinson’s Disease Protein LRRK2 Interacts with the GARP Complex to Promote Retrograde Transport to the trans-Golgi Network

Alexandra Beilina, Luis Bonet‐Ponce, Ravindran Kumaran, +14

Cell Reports

Lrrk2 ToxicityKinase InhibitorsMolecular BiologyDopamine NeuronsCellular Physiology +17

Mutations in LRRK2 linked to Parkinson disease sequester Rab8a to damaged lysosomes and regulate transferrin-mediated iron uptake in microglia

Adamantios Mamais, Jillian H. Kluss, Luis Bonet‐Ponce, +15

PLoS Biology

MitophagyImmunologyCell DeathNeuroinflammationReceptor Tyrosine Kinase +17