The clonal and mutational evolution spectrum of primary triple-negative breast cancers

Sohrab P. Shah, Andrew Roth, Rodrigo Goya, +56

Nature

Breast OncologyTumor HeterogeneityMedicinePathologyCancer Genomics +8

Dynamics of genomic clones in breast cancer patient xenografts at single-cell resolution

Peter Eirew, Adi Steif, Jaswinder Khattra, +43

Nature

XenotransplantationSomatic VariantTumor HeterogeneitySingle-cell ResolutionMedicine +10

Distinct evolutionary trajectories of primary high‐grade serous ovarian cancers revealed through spatial mutational profiling

Ali Bashashati, Gavin Ha, Alicia Tone, +22

The Journal of Pathology

TITAN: inference of copy number architectures in clonal cell populations from tumor whole-genome sequence data

Gavin Ha, Andrew Roth, Jaswinder Khattra, +18

Genome Research

Clonal Cell PopulationsEngineeringCopy Number ArchitecturesGeneticsGenomics +17

Divergent modes of clonal spread and intraperitoneal mixing in high-grade serous ovarian cancer

Andrew McPherson, Andrew Roth, Emma Laks, +31

Nature Genetics

Surgical OncologyTumoral PathologyMedicineClonal SpreadDivergent Modes +7

DriverNet: uncovering the impact of somatic driver mutations on transcriptional networks in cancer

Ali Bashashati, Gholamreza Haffari, Jiarui Ding, +7

Genome biology

Integrative analysis of genome-wide loss of heterozygosity and monoallelic expression at nucleotide resolution reveals disrupted pathways in triple-negative breast cancer

Gavin Ha, Andrew Roth, Daniel Lai, +14

Genome Research

Breast OncologyGeneticsTranscriptomics TechnologyIntegrative AnalysisTumor Biology +14

Histological Transformation and Progression in Follicular Lymphoma: A Clonal Evolution Study

Robert Kridel, Fong Chun Chan, Anja Mottok, +29

PLoS Medicine

CLK-dependent exon recognition and conjoined gene formation revealed with a novel small molecule inhibitor

Tyler Funnell, Shinya Tasaki, Arusha Oloumi, +33

Nature Communications

Recurrent <i><scp>DICER1</scp></i> hotspot mutations in endometrial tumours and their impact on <scp>microRNA</scp> biogenesis

Jiamin Chen, Yemin Wang, Melissa K McMonechy, +11

The Journal of Pathology

EngineeringGeneticsCell ProliferationCell CycleEpigenetics +15