Carrie O’Connor

Novel Pyrrolo[3,2- <i>d</i> ]pyrimidine Compounds Target Mitochondrial and Cytosolic One-carbon Metabolism with Broad-spectrum Antitumor Efficacy

Aamod S. Dekhne, Khushbu Shah, Gregory S. Ducker et al. · Molecular Cancer Therapeutics · 2019 · 56 citations · Full text

Life Sciences, Oncology, Pharmacology +16

Dual Targeting of Epithelial Ovarian Cancer Via Folate Receptor α and the Proton-Coupled Folate Transporter with 6-Substituted Pyrrolo[2,3- <i>d</i> ]pyrimidine Antifolates

Zhanjun Hou, Leda Gattoc, Carrie O’Connor et al. · Molecular Cancer Therapeutics · 2017 · 41 citations · Full text

Medicine, Oncology, Pharmacology +13

6-Substituted Pyrrolo[2,3-<i>d</i>]pyrimidine Thienoyl Regioisomers as Targeted Antifolates for Folate Receptor α and the Proton-Coupled Folate Transporter in Human Tumors

Lei Wang, Adrianne Wallace-Povirk, Sudhir Raghavan et al. · Journal of Medicinal Chemistry · 2015 · 39 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +13

Cellular Pharmacodynamics of a Novel Pyrrolo[3,2-d]pyrimidine Inhibitor Targeting Mitochondrial and Cytosolic One-Carbon Metabolism

Aamod S. Dekhne, Changwen Ning, Md. Junayed Nayeen et al. · Molecular Pharmacology · 2019 · 37 citations · Full text

Life Sciences, Medicinal Chemistry, Pharmacology +17

Folate transporter dynamics and therapy with classic and tumor-targeted antifolates

Carrie O’Connor, Adrianne Wallace-Povirk, Changwen Ning et al. · Scientific Reports · 2021 · 33 citations · Full text

Medicine, Oncology, Pharmacology +13