Carrie O’Connor

Novel Pyrrolo[3,2- <i>d</i> ]pyrimidine Compounds Target Mitochondrial and Cytosolic One-carbon Metabolism with Broad-spectrum Antitumor Efficacy

Aamod S. Dekhne, Khushbu Shah, Gregory S. Ducker et al. · Molecular Cancer Therapeutics · 2019 · 51 citations · Full text

Dual Targeting of Epithelial Ovarian Cancer Via Folate Receptor α and the Proton-Coupled Folate Transporter with 6-Substituted Pyrrolo[2,3- <i>d</i> ]pyrimidine Antifolates

Zhanjun Hou, Leda Gattoc, Carrie O’Connor et al. · Molecular Cancer Therapeutics · 2017 · 40 citations · Full text

6-Substituted Pyrrolo[2,3-<i>d</i>]pyrimidine Thienoyl Regioisomers as Targeted Antifolates for Folate Receptor α and the Proton-Coupled Folate Transporter in Human Tumors

Lei Wang, Adrianne Wallace-Povirk, Sudhir Raghavan et al. · Journal of Medicinal Chemistry · 2015 · 38 citations · Full text

Chemical Biology, Pharmaceutical Chemistry, Tumor Biology +19

Cellular Pharmacodynamics of a Novel Pyrrolo[3,2-d]pyrimidine Inhibitor Targeting Mitochondrial and Cytosolic One-Carbon Metabolism

Aamod S. Dekhne, Changwen Ning, Md. Junayed Nayeen et al. · Molecular Pharmacology · 2019 · 35 citations · Full text

Tumor Targeting with Novel 6-Substituted Pyrrolo [2,3-<i>d</i>] Pyrimidine Antifolates with Heteroatom Bridge Substitutions via Cellular Uptake by Folate Receptor α and the Proton-Coupled Folate Transporter and Inhibition of de Novo Purine Nucleotide Biosynthesis

Lalit K. Golani, Adrianne Wallace-Povirk, S.M. Deis et al. · Journal of Medicinal Chemistry · 2016 · 31 citations · Full text

Pharmaceutical Chemistry, Tumor Biology, Medicinal Chemistry +20