John R. Koenig

Novel Transient Receptor Potential Vanilloid 1 Receptor Antagonists for the Treatment of Pain:  Structure−Activity Relationships for Ureas with Quinoline, Isoquinoline, Quinazoline, Phthalazine, Quinoxaline, and Cinnoline Moieties

Arthur Gomtsyan, Erol K. Bayburt, Robert G. Schmidt et al. · Journal of Medicinal Chemistry · 2005 · 163 citations · Full text

Pain Medicine, Immunology, Receptor Antagonists +18

A-995662 [(R)-8-(4-methyl-5-(4-(trifluoromethyl)phenyl)oxazol-2-ylamino)-1,2,3,4-tetrahydronaphthalen-2-ol], a novel, selective TRPV1 receptor antagonist, reduces spinal release of glutamate and CGRP in a rat knee joint pain model

Pamela S. Puttfarcken, Ping Han, Shailen K. Joshi et al. · Pain · 2010 · 64 citations

Tetrahydropyridine-4-carboxamides as novel, potent transient receptor potential vanilloid 1 (TRPV1) antagonists

Brian S. Brown, Ryan G. Keddy, Guo Zhu Zheng et al. · Bioorganic & Medicinal Chemistry · 2008 · 48 citations · Full text

Biochemistry, Functional Selectivity, Medicine +3

Adenosine kinase inhibitors: polar 7-Substitutent of pyridopyrimidine derivatives improving their locomotor selectivity

Guo Zhu Zheng, Yue Mao, Chih‐Hung Lee et al. · Bioorganic & Medicinal Chemistry Letters · 2003 · 43 citations · Full text

Molecular Pharmacology, Pyridopyrimidine Derivatives, Molecular Physiology +9

Chroman and tetrahydroquinoline ureas as potent TRPV1 antagonists

Robert G. Schmidt, Erol K. Bayburt, Steven P. Latshaw et al. · Bioorganic & Medicinal Chemistry Letters · 2011 · 39 citations · Full text

Molecular Pharmacology, Medicinal Chemistry, Medicine +5