Arthur Gomtsyan

Heterocycles in drugs and drug discovery

Arthur Gomtsyan · Chemistry of Heterocyclic Compounds · 2012 · 599 citations

Pharmacy, Chemistry, Medicinal Chemistry +12

TRPV1 Receptors in the CNS Play a Key Role in Broad-Spectrum Analgesia of TRPV1 Antagonists

Minghua Cui, Prisca Honoré, Chengmin Zhong et al. · Journal of Neuroscience · 2006 · 314 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +15

A-425619 [1-Isoquinolin-5-yl-3-(4-trifluoromethyl-benzyl)-urea], a Novel Transient Receptor Potential Type V1 Receptor Antagonist, Relieves Pathophysiological Pain Associated with Inflammation and Tissue Injury in Rats

Prisca Honoré, Carol T. Wismer, Joe Mikusa et al. · Journal of Pharmacology and Experimental Therapeutics · 2005 · 255 citations

Medicine, Neuroscience, Pharmacology +17

Novel Transient Receptor Potential Vanilloid 1 Receptor Antagonists for the Treatment of Pain:  Structure−Activity Relationships for Ureas with Quinoline, Isoquinoline, Quinazoline, Phthalazine, Quinoxaline, and Cinnoline Moieties

Arthur Gomtsyan, Erol K. Bayburt, Robert G. Schmidt et al. · Journal of Medicinal Chemistry · 2005 · 163 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +16

Repeated dosing of ABT-102, a potent and selective TRPV1 antagonist, enhances TRPV1-mediated analgesic activity in rodents, but attenuates antagonist-induced hyperthermia

Prisca Honoré, Prasant Chandran, Gricelda Hernandez et al. · Pain · 2009 · 146 citations

Medicine, Medicinal Chemistry, Pharmacology +17