A-317491, a novel potent and selective non-nucleotide antagonist of P2X ₃ and P2X _2/3 receptors, reduces chronic inflammatory and neuropathic pain in the rat

Michael F. Jarvis, Edward C. Burgard, Steve McGaraughty, +22

Proceedings of the National Academy of Sciences

A-425619 [1-Isoquinolin-5-yl-3-(4-trifluoromethyl-benzyl)-urea], a Novel Transient Receptor Potential Type V1 Receptor Antagonist, Relieves Pathophysiological Pain Associated with Inflammation and Tissue Injury in Rats

Prisca Honoré, Carol T. Wismer, Joe Mikusa, +10

Journal of Pharmacology and Experimental Therapeutics

P2X7-related modulation of pathological nociception in rats

Steve McGaraughty, K. L. Chu, Marian T. Namovic, +16

Neuroscience

Health SciencesPain MedicineP2x7-related ModulationPhysiologyMedicine +6

Effects of A‐317491, a novel and selective P2X₃/P2X_2/3 receptor antagonist, on neuropathic, inflammatory and chemogenic nociception following intrathecal and intraplantar administration

Steve McGaraughty, Carol T. Wismer, Chang Zhu, +6

British Journal of Pharmacology

Novel Transient Receptor Potential Vanilloid 1 Receptor Antagonists for the Treatment of Pain:  Structure−Activity Relationships for Ureas with Quinoline, Isoquinoline, Quinazoline, Phthalazine, Quinoxaline, and Cinnoline Moieties

Arthur Gomtsyan, Erol K. Bayburt, Robert G. Schmidt, +20

Journal of Medicinal Chemistry

Pain MedicineImmunologyReceptor AntagonistsNeuropathic PainMolecular Pain +16

Modulation of BzATP and formalin induced nociception: attenuation by the P2X receptor antagonist, TNP‐ATP and enhancement by the P2X₃ allosteric modulator, cibacron blue

Michael F. Jarvis, Carol T. Wismer, Edmund Schweitzer, +5

British Journal of Pharmacology

Pain MedicineAnesthetic MechanismNeuropathic PainMolecular PainPharmacotherapy +22

ABT-702 (4-Amino-5-(3-bromophenyl)-7-(6-morpholino-pyridin- 3-yl)pyrido[2,3-d]pyrimidine), a Novel Orally Effective Adenosine Kinase Inhibitor with Analgesic and Anti-Inflammatory Properties. II. In Vivo Characterization in the Rat

Elizabeth A. Kowaluk, Carol T. Wismer, C.Z. Zhu, +8

Journal of Pharmacology and Experimental Therapeutics

Assessing the role of metabotropic glutamate receptor 5 in multiple nociceptive modalities

Chang Zhu, Sonya G. Wilson, Joseph P. Mikusa, +6

European Journal of Pharmacology

Pain SyndromeNeurophysiologyPain MedicineMultiple Nociceptive ModalitiesMedicine +9

Comparison of antinociceptive actions of standard analgesics in attenuating capsaicin and nerve-injury-induced mechanical hypersensitivity

S. K. Joshi, Gricelda Hernandez, Joe Mikusa, +7

Neuroscience

Nerve-injury-induced Mechanical HypersensitivityAllergyHealth SciencesAcute PainPain Medicine +12

Design, Synthesis, and Structure−Activity Relationship of 6-Alkynylpyrimidines as Potent Adenosine Kinase Inhibitors

Arthur Gomtsyan, Stanley DiDomenico, Chih‐Hung Lee, +9

Journal of Medicinal Chemistry

Ak InhibitorsMolecular PharmacologyCombinatorial ChemistryAnti-inflammatoryBiochemistry +13