Mitochondrial complex III is required for hypoxia-induced ROS production and cellular oxygen sensing

Robert D. Guzy, Beatrice Hoyos, Emmanuel Robin, +6

Cell Metabolism

Mitochondrial FunctionBiochemistryNatural SciencesCellular OxygenMolecular Biology +7

Single-Cell Transcriptomic Analysis of Human Lung Provides Insights into the Pathobiology of Pulmonary Fibrosis

Paul A. Reyfman, James M. Walter, Nikita Joshi, +46

American Journal of Respiratory and Critical Care Medicine

Mitochondrial dysfunction resulting from loss of cytochrome c impairs cellular oxygen sensing and hypoxic HIF-α activation

Kyle D. Mansfield, Robert D. Guzy, Yi Pan, +4

Cell Metabolism

Redox SignalingBiochemistryMitochondrial FunctionMitochondrial DysfunctionPhysiology +9

Loss of the SdhB, but Not the SdhA, Subunit of Complex II Triggers Reactive Oxygen Species-Dependent Hypoxia-Inducible Factor Activation and Tumorigenesis

Robert D. Guzy, Bhumika Sharma, Eric L. Bell, +2

Molecular and Cellular Biology

Redox BiologyTumor BiologyOxidative StressMitochondrial Complex IiMitochondrial Biogenesis +15

Hypoxia Triggers Subcellular Compartmental Redox Signaling in Vascular Smooth Muscle Cells

Gregory B. Waypa, Jeremy D. Marks, Robert D. Guzy, +3

Circulation Research

Mitochondrial oxidant stress triggers cell death in simulated ischemia–reperfusion

Gabriel Loor, Jyothisri Kondapalli, Hirotaro Iwase, +5

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

InflammationMitochondrial FunctionReperfusion InjuryPhysiologyCell Death +6

Increases in Mitochondrial Reactive Oxygen Species Trigger Hypoxia-Induced Calcium Responses in Pulmonary Artery Smooth Muscle Cells

Gregory B. Waypa, Robert D. Guzy, Paul T. Mungai, +4

Circulation Research

Lipid PeroxidationRedox BiologyCellular PhysiologyOxidative StressHypoxia Triggers +20

Superoxide Generated at Mitochondrial Complex III Triggers Acute Responses to Hypoxia in the Pulmonary Circulation

Gregory B. Waypa, Jeremy D. Marks, Robert D. Guzy, +4

American Journal of Respiratory and Critical Care Medicine

Oxidant Stress during Simulated Ischemia Primes Cardiomyocytes for Cell Death during Reperfusion

Emmanuel Robin, Robert D. Guzy, Gabriel Loor, +5

Journal of Biological Chemistry

Fibroblast-enriched endoplasmic reticulum protein TXNDC5 promotes pulmonary fibrosis by augmenting TGFβ signaling through TGFBR1 stabilization

Tzu-Han Lee, Chih‐Fan Yeh, Ying-Tung Lee, +23

Nature Communications