Single-Cell Transcriptomic Analysis of Human Lung Provides Insights into the Pathobiology of Pulmonary Fibrosis

Paul A. Reyfman, James M. Walter, Nikita Joshi, +46

American Journal of Respiratory and Critical Care Medicine

Monocyte-derived alveolar macrophages drive lung fibrosis and persist in the lung over the life span

Alexander V. Misharin, Luisa Morales‐Nebreda, Paul A. Reyfman, +40

The Journal of Experimental Medicine

Acute Lung InjuryMonocyte-derived Alveolar MacrophagesInflammatory Lung DiseaseAdvanced Lung DiseaseLung Inflammation +17

A spatially restricted fibrotic niche in pulmonary fibrosis is sustained by M-CSF/M-CSFR signalling in monocyte-derived alveolar macrophages

Nikita Joshi, Satoshi Watanabe, Rohan Verma, +18

European Respiratory Journal

The lung microenvironment shapes a dysfunctional response of alveolar macrophages in aging

Alexandra C. McQuattie‐Pimentel, Ziyou Ren, Nikita Joshi, +31

Journal of Clinical Investigation

AgingInflammatory Lung DiseaseLung InflammationAdvanced Lung DiseaseImmunology +16

Resetting proteostasis with ISRIB promotes epithelial differentiation to attenuate pulmonary fibrosis

Satoshi Watanabe, Nikolay S. Markov, Ziyan Lu, +21

Proceedings of the National Academy of Sciences

Thrombin Inhibition with Dabigatran Protects against High-Fat Diet–Induced Fatty Liver Disease in Mice

Anna K. Kopec, Nikita Joshi, Keara Towery, +4

Journal of Pharmacology and Experimental Therapeutics

Fibrin(ogen) drives repair after acetaminophen-induced liver injury via leukocyte αMβ2 integrin-dependent upregulation of Mmp12

Anna K. Kopec, Nikita Joshi, Holly Cline-Fedewa, +7

Journal of Hepatology

InflammationFibrosisLiver PhysiologyImmunologyHepatology Inflammation +9

Platelets and protease-activated receptor-4 contribute to acetaminophen-induced liver injury in mice

Kazuhisa Miyakawa, Nikita Joshi, Bradley P. Sullivan, +8

Blood

Hepatocyte tissue factor activates the coagulation cascade in mice

Bradley P. Sullivan, Anna K. Kopec, Nikita Joshi, +7

Blood

RNA Sequencing Identifies Novel Translational Biomarkers of Kidney Fibrosis

Florin L. Craciun, Vanesa Bijol, Amrendra K. Ajay, +13

Journal of the American Society of Nephrology