IL-23 drives a pathogenic T cell population that induces autoimmune inflammation

Claire L. Langrish, Yi Chen, Wendy M. Blumenschein, +6

The Journal of Experimental Medicine

Development, cytokine profile and function of human interleukin 17–producing helper T cells

Nicholas J. Wilson, Katia Boniface, Jason R. Chan, +13

Nature Immunology

InflammationCytokineImmune Cell DevelopmentImmunologyT Cell Immunity +8

IL-23 is essential for T cell–mediated colitis and promotes inflammation via IL-17 and IL-6

David Yen, Jeanne Cheung, Heleen Scheerens, +12

Journal of Clinical Investigation

Chronic Inflammatory DiseasesImmunologyImmune RegulationPathologyMouse Ibd Studies +15

IL-27, a Heterodimeric Cytokine Composed of EBI3 and p28 Protein, Induces Proliferation of Naive CD4+ T Cells

Stefan Pflanz, Jackie C. Timans, Jeanne Cheung, +18

Immunity

InflammationCytokineAutoimmune DiseaseP28 ProteinHeterodimeric Cytokine +9

IL-23 promotes tumour incidence and growth

John L. Langowski, Xueqing Zhang, Lingling Wu, +7

Nature

Cancer ImmunosurveillanceT-regulatory CellImmunologyIl-23 PromotesMedicine +1

WSX-1 and Glycoprotein 130 Constitute a Signal-Transducing Receptor for IL-27

Stefan Pflanz, Linda Hibbert, Jeanine Mattson, +7

The Journal of Immunology

Ligand for FLT3/FLK2 receptor tyrosine kinase regulates growth of haematopoietic stem cells and is encoded by variant RNAs

Charles Hannum, Janice Culpepper, D Campbell, +23

Nature

Developmental BiologySignaling PathwayHaematopoietic Stem CellsMedicineReceptor Tyrosine Kinase +8

B7 and interleukin 12 cooperate for proliferation and interferon gamma production by mouse T helper clones that are unresponsive to B7 costimulation.

Ellen Murphy, Geronimo Terres, S E Macatonia, +7

The Journal of Experimental Medicine

Interferon Gamma ProductionLymphocyte DevelopmentAdaptive Immune SystemT-regulatory CellImmunology +20

CD94 and a Novel Associated Protein (94AP) Form a NK Cell Receptor Involved in the Recognition of HLA-A, HLA-B, and HLA-C Allotypes

Joseph H. Phillips, Chiwen Chang, Jeanine Mattson, +3

Immunity

HistocompatibilityNovel Associated ProteinAutoimmune DiseaseHuman Leukocyte AntigenHla-c Allotypes +7

Autoimmune Memory T Helper 17 Cell Function and Expansion Are Dependent on Interleukin-23

Christopher J. Haines, Yi Chen, Wendy M. Blumenschein, +12

Cell Reports