Ed Wancewicz

2‘-<i>O</i>-Aminopropyl Ribonucleotides:  A Zwitterionic Modification That Enhances the Exonuclease Resistance and Biological Activity of Antisense Oligonucleotides

Richard H. Griffey, Brett P. Monia, Lendall L. Cummins et al. · Journal of Medicinal Chemistry · 1996 · 127 citations

Nucleic Acid Chemistry, Bioorganic Chemistry, Sugar Proton Resonances +15

SOD1 in Cerebral Spinal Fluid as a Pharmacodynamic Marker for Antisense Oligonucleotide Therapy

Leah Winer, Dushyanth Srinivasan, Seung Chun et al. · JAMA Neurology · 2012 · 108 citations · Full text

Effect of dose and plasma concentration on liver uptake and pharmacologic activity of a 2′-methoxyethyl modified chimeric antisense oligonucleotide targeting PTEN

Richard S. Geary, Ed Wancewicz, John Matson et al. · Biochemical Pharmacology · 2009 · 82 citations

Pharmacologic Activity, Drug Targeting, Biochemistry +7

Intracerebral Infusion of Antisense Oligonucleotides Into Prion-infected Mice

Karah Nazor Friberg, Gene Hung, Ed Wancewicz et al. · Molecular Therapy — Nucleic Acids · 2012 · 59 citations · Full text

Development of a simple, rapid, and robust intrathecal catheterization method in the rat

Curt Mazur, Bethany Fitzsimmons, Fredrik Kamme et al. · Journal of Neuroscience Methods · 2017 · 37 citations

Anesthesia Practice, Electrophysiology, Biomedical Engineering +4