Andres McKenzie

Small molecules inhibit the interaction of Nrf2 and the Keap1 Kelch domain through a non-covalent mechanism

D.J. Marcotte, Weike Zeng, Jean‐Christophe Hus et al. · Bioorganic & Medicinal Chemistry · 2013 · 238 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +14

BIIB021, an orally available, fully synthetic small-molecule inhibitor of the heat shock protein Hsp90

Karen Lundgren, Hong Zhang, John Brekken et al. · Molecular Cancer Therapeutics · 2009 · 170 citations · Full text

Medicine, Oncology, Pharmacology +12

EC144 Is a Potent Inhibitor of the Heat Shock Protein 90

Jiandong Shi, Ryan W. Van De Water, Kevin Hong et al. · Journal of Medicinal Chemistry · 2012 · 72 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +10

Discovery of biaryls as RORγ inverse agonists by using structure-based design

Istvan Enyedy, Noel A. Powell, Justin A. Caravella et al. · Bioorganic & Medicinal Chemistry Letters · 2016 · 19 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +14

Oncogenic MST1R activity in pancreatic and gastric cancer represents a valid target of HSP90 inhibitors.

Christian Moser, Sven A. Lang, Christina Hackl et al. · PubMed · 2012 · 11 citations

Medicine, Cancer Biology, Oncology +15