Linkage disequilibrium–dependent architecture of human complex traits shows action of negative selection

Steven Gazal, Hilary K. Finucane, Nicholas A. Furlotte, +8

Nature Genetics

Linkage DisequilibriumMedicineGeneticsEvolutionary BiologyLinkage Analysis +9

Trans Effects on Gene Expression Can Drive Omnigenic Inheritance

Xuanyao Liu, Yang Li, Jonathan K. Pritchard

Cell

Trans EffectsGenetic DisorderGeneticsGenomic MechanismGenetic Mechanism +3

Leveraging molecular quantitative trait loci to understand the genetic architecture of diseases and complex traits

Farhad Hormozdiari, Steven Gazal, Bryce van de Geijn, +10

Nature Genetics

Genome-wide Association StudyGenetic AnalysisGenetic DiseasesComplex Trait GeneticsQuantitative Genetics +12

Deep Whole-Genome Sequencing of 100 Southeast Asian Malays

Lai-Ping Wong, Rick Twee‐Hee Ong, Wan-Ting Poh, +27

The American Journal of Human Genetics

PhylogeneticsNext-generation SequencingGeneticsGenome SequencingGenomics +4

Functional Architectures of Local and Distal Regulation of Gene Expression in Multiple Human Tissues

Xuanyao Liu, Hilary K. Finucane, Alexander Gusev, +8

The American Journal of Human Genetics

Functional GenomicsMolecular PhysiologySignal TransductionGene RegulationFunctional Regulation +9

Detecting and Characterizing Genomic Signatures of Positive Selection in Global Populations

Xuanyao Liu, Rick Twee‐Hee Ong, Esakimuthu Nisha Pillai, +5

The American Journal of Human Genetics

GeneticsNatural SelectionGenomicsGenomic SelectionGenetic Analysis +16

Comparing methods for performing trans-ethnic meta-analysis of genome-wide association studies

Xu Wang, Hui-Xiang Chua, Peng Chen, +18

Human Molecular Genetics

EthnicityGenetic EpidemiologyEducationGenome-wide Association StudiesRace +14

Insights into the Genetic Structure and Diversity of 38 South Asian Indians from Deep Whole-Genome Sequencing

Lai-Ping Wong, Jason Lai, Woei‐Yuh Saw, +16

PLoS Genetics

Comparative GenomicsGeneticsSouth Asian IndiansGenomicsPhylogenetics +16

Evaluating the contribution of rare variants to type 2 diabetes and related traits using pedigrees

Goo Jun, Alisa K. Manning, Marcio Almeida, +70

Proceedings of the National Academy of Sciences

Characterizing the genetic differences between two distinct migrant groups from Indo-European and Dravidian speaking populations in India

Mohammad Ali, Xuanyao Liu, Esakimuthu Nisha Pillai, +4

BMC Genetics