Pathophysiological role of endothelin revealed by the first orally active endothelin receptor antagonist

Martine Clozel, Volker Breu, Kaspar F. Burri, +8

Nature

MedicineVascular PharmacologyPhysiologyEndothelial DysfunctionVascular Biology +3

Pharmacology of Tezosentan, New Endothelin Receptor Antagonist Designed for Parenteral Use

M Clozel, Henri Ramuz, Jean-Paul Clozel, +5

Journal of Pharmacology and Experimental Therapeutics

Ro 61–1790, a New Hydrosoluble Endothelin Antagonist: General Pharmacology and Effects on Experimental Cerebral Vasospasm

Sébastiên Roux, Volker Breu, Thomas Giller, +5

Journal of Pharmacology and Experimental Therapeutics

Novel Benzo[1,4]diazepin-2-one Derivatives as Endothelin Receptor Antagonists

Martin H. Bolli, Judith Marfurt, Corinna Grisostomi, +12

Journal of Medicinal Chemistry

Separable Binding Sites for the Natural Agonist Endothelin-1 and the Non-Peptide Antagonist Bosentan on Human Endothelin-A Receptors

Volker Breu, Kento Hashido, Clemens Broger, +7

European Journal of Biochemistry

Functional SelectivityMedicinePhysiologySeparable Binding SitesReceptor (Biochemistry) +6

Separable Binding Sites for the Natural Agonist Endothelin-1 and the Non-Peptide Antagonist Bosentan on Human Endothelin-A Receptors

Volker Breu, Kento Hashido, Clemens Broger, +7

European Journal of Biochemistry

Chemical BiologyHuman Endothelin-a ReceptorMedicinal ChemistryActive EndothelinSeparable Binding Sites +18

In vitro characterisation of Ro 46‐8443, the first non‐peptide antagonist selective for the endothelin ET_B receptor

Volker Breu, Martine Clozel, Kaspar F. Burri, +3

FEBS Letters

Ro 46-8443Etb ReceptorsImmunologyPharmacotherapyMolecular Pharmacology +16

Discovery of Ro 48-5695: A potent mixed endothelin receptor antagonist optimized from bosentan

Werner Neidhart, Volker Breu, Kaspar F. Burri, +5

Bioorganic & Medicinal Chemistry Letters

Molecular PharmacologyBiochemistryFunctional SelectivityMedicinePhysiology +4

Optically Pure Isoproterenol Analogues With Side Chains Containing an Amide Bond: Synthesis and biological properties

Hans Peter Märki, Yvo Crameri, R Eigenmann, +5

Helvetica Chimica Acta

Biological PropertiesOrganic ChemistryPharmacotherapyExperimental PharmacologyPharmaceutical Chemistry +15

Human multi‐drug‐resistant cancer cells exhibit a high degree of selectivity for stereoisomers of verapamil and quinidine

James F. Eliason, Henri Ramuz, Franz Kaufmann

International Journal of Cancer