FDA Approval Summary: Lutetium Lu 177 Vipivotide Tetraxetan for Patients with Metastatic Castration-Resistant Prostate Cancer

Jaleh Fallah, Sundeep Agrawal, Haley Gittleman, +16

Clinical Cancer Research

UrologyDry MouthGenitourinary CancerFda ReviewMedicine +12

PRMT5 Is a Critical Regulator of Breast Cancer Stem Cell Function via Histone Methylation and FOXP1 Expression

Kelly Chiang, Agnieszka Zielińska, Abeer M. Shaaban, +12

Cell Reports

Epigenetic ChangeCancer BiologyTreatment ResistanceEpigeneticsTumor Biology +20

PRMT5-Dependent Methylation of the TIP60 Coactivator RUVBL1 Is a Key Regulator of Homologous Recombination

Thomas L. Clarke, María Pilar Sánchez-Bailón, Kelly Chiang, +8

Molecular Cell

Metabolic strategy of boar spermatozoa revealed by a metabolomic characterization

Silvia Marín, Kelly Chiang, Sara Bassilian, +7

FEBS Letters

Complex Exon-Intron Marking by Histone Modifications Is Not Determined Solely by Nucleosome Distribution

Pawandeep Dhami, Peter Saffrey, Alexander W. Bruce, +13

PLoS ONE

Histone ModificationsEpigenetic ChangeGeneticsRna SplicingMolecular Biology +22

Arginine methylation and ubiquitylation crosstalk controls DNA end-resection and homologous recombination repair

María Pilar Sánchez-Bailón, Soo‐Youn Choi, Elizabeth R. Dufficy, +10

Nature Communications

FDA Approval Summary: Margetuximab plus Chemotherapy for Advanced or Metastatic HER2-Positive Breast Cancer

Melanie Royce, Christy Osgood, Anup Amatya, +34

Clinical Cancer Research

Genomic Approaches Uncover Increasing Complexities in the Regulatory Landscape at the Human SCL (TAL1) Locus

Pawandeep Dhami, Alexander W. Bruce, Johanna H. Jim, +9

PLoS ONE

Regulatory LandscapeGeneticsGenomic MechanismGene CharacterizationHuman Scl +19

PRMT5-regulated splicing of DNA repair genes drives chemoresistance in breast cancer stem cells

Matthew S. Gillespie, Kelly Chiang, Gemma L. Regan-Mochrie, +6

Oncogene

Linking PRMT5 to breast cancer stem cells: New therapeutic opportunities?

Kelly Chiang, Clare C. Davies

Molecular & Cellular Oncology

Breast OncologyEpigenetic ChangeArginine Methyltransferase Prmt5EpigeneticsTumor Biology +19