Thomas L. Clarke

PRMT5 Is a Critical Regulator of Breast Cancer Stem Cell Function via Histone Methylation and FOXP1 Expression

Kelly Chiang, Agnieszka Zielińska, Abeer M. Shaaban et al. · Cell Reports · 2017 · 199 citations · Full text

Epigenetic Change, Cancer Biology, Treatment Resistance +22

PRMT5-Dependent Methylation of the TIP60 Coactivator RUVBL1 Is a Key Regulator of Homologous Recombination

Thomas L. Clarke, María Pilar Sánchez-Bailón, Kelly Chiang et al. · Molecular Cell · 2017 · 169 citations · Full text

Cross-talk between Lysine-Modifying Enzymes Controls Site-Specific DNA Amplifications

Sweta Mishra, Capucine Van Rechem, Sangita Pal et al. · Cell · 2018 · 49 citations · Full text

Cellular Enzymology, Natural Sciences, Dna Replication +3

Histone Lysine Methylation Dynamics Control <i>EGFR</i> DNA Copy-Number Amplification

Thomas L. Clarke, Ran Tang, Damayanti Chakraborty et al. · Cancer Discovery · 2019 · 46 citations · Full text

AI/ML combined with next-generation sequencing of VHH immune repertoires enables the rapid identification of de novo humanized and sequence-optimized single domain antibodies: a prospective case study

Paul Arras, Han Byul Yoo, Lukas Pekar et al. · Frontiers in Molecular Biosciences · 2023 · 22 citations · Full text