Greg Markby

<scp>TGF‐β</scp>‐induced <scp>PI3K</scp>/<scp>AKT</scp>/<scp>mTOR</scp> pathway controls myofibroblast differentiation and secretory phenotype of valvular interstitial cells through the modulation of cellular senescence in a naturally occurring in vitro canine model of myxomatous mitral valve disease

Qiyu Tang, Greg Markby, Andrew J. MacNair et al. · Cell Proliferation · 2023 · 66 citations · Full text

Life Sciences, Cardiology, Molecular Biology +15

Disease Severity-Associated Gene Expression in Canine Myxomatous Mitral Valve Disease Is Dominated by TGFβ Signaling

Greg Markby, Vicky E. MacRae, Kim Summers et al. · Frontiers in Genetics · 2020 · 47 citations · Full text

Life Sciences, Cardiology, Molecular Biology +17

Investigation of the specificity and mechanism of action of the ULK1/AMPK inhibitor SBI-0206965

Danial Ahwazi, Katyayanee Neopane, Greg Markby et al. · Biochemical Journal · 2021 · 47 citations · Full text

Life Sciences, Biochemistry, Pharmacology +14

Evaluation of canine 2D cell cultures as models of myxomatous mitral valve degeneration

Karen A. L. Tan, Greg Markby, R. H. Muirhead et al. · PLoS ONE · 2019 · 28 citations · Full text

Life Sciences, Cell Biology, Pathobiology +14

Autophagy regulates cellular senescence by mediating the degradation of CDKN1A/p21 and CDKN2A/p16 through SQSTM1/p62-mediated selective autophagy in myxomatous mitral valve degeneration

Qiyu Tang, Keyi Tang, Greg Markby et al. · Autophagy · 2025 · 24 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +17