Lu-Lin Jiang

TREM2 Is a Receptor for β-Amyloid that Mediates Microglial Function

Yingjun Zhao, Xilin Wu, Xiaoguang Li et al. · Neuron · 2018 · 761 citations · Full text

Neurodegenerative Diseases, Microglial Function, Medicine +6

Elevated TREM2 Gene Dosage Reprograms Microglia Responsivity and Ameliorates Pathological Phenotypes in Alzheimer’s Disease Models

C.Y. Daniel Lee, Anthony Daggett, Xiaofeng Gu et al. · Neuron · 2018 · 410 citations · Full text

Disease Models, Neurodegenerative Diseases, Molecular Neuroscience +15

Reduced C9ORF72 function exacerbates gain of toxicity from ALS/FTD-causing repeat expansion in C9orf72

Qiang Zhu, Jie Jiang, Tania F. Gendron et al. · Nature Neuroscience · 2020 · 224 citations · Full text

C9orf72 Function, Amyotrophic Lateral Sclerosis, Medicine +4

A tetravalent TREM2 agonistic antibody reduced amyloid pathology in a mouse model of Alzheimer’s disease

Peng Zhao, Yuanzhong Xu, Lu-Lin Jiang et al. · Science Translational Medicine · 2022 · 117 citations

Immunology, Immune Regulation, Microglia Migration +26

ER-associated degradation regulates Alzheimer’s amyloid pathology and memory function by modulating γ-secretase activity

Bing Zhu, Lu-Lin Jiang, Timothy Y. Huang et al. · Nature Communications · 2017 · 71 citations · Full text

Erad Complex, γ-Secretase Activity, Synaptic Signaling +22