Kym N. Lowes

Exploiting selective BCL-2 family inhibitors to dissect cell survival dependencies and define improved strategies for cancer therapy

Darren C. Phillips, Michael J. Mitten, Erwin R. Boghaert et al. · Science Translational Medicine · 2015 · 530 citations · Full text

Cancer Therapy, Chemoprevention Strategy, Bcl-2/bcl-xl/bcl-w Inhibitor Abt-263 +20

Mechanism and inhibition of the papain‐like protease, PLpro, of SARS‐CoV‐2

Theresa Klemm, Gregor Ebert, Dale J. Calleja et al. · The EMBO Journal · 2020 · 478 citations · Full text

Protein Function, Biochemistry, Natural Sciences +3

Oval Cell Numbers in Human Chronic Liver Diseases Are Directly Related to Disease Severity

Kym N. Lowes, Barbara A. Brennan, George C. Yeoh et al. · American Journal Of Pathology · 1999 · 448 citations

Hepatology, Autoimmune Disease, Disease Severity +15

Structure-guided design of a selective BCL-XL inhibitor

Guillaume Lessène, Peter E. Czabotar, Brad E. Sleebs et al. · Nature Chemical Biology · 2013 · 370 citations · Full text

Drug Target, Medicine, Rational Drug Design +4

βTrCP- and Rsk1/2-Mediated Degradation of BimEL Inhibits Apoptosis

Elinor Dehan, Florian Bassermann, Daniele Guardavaccaro et al. · Molecular Cell · 2009 · 192 citations · Full text

Bimel Inhibits Apoptosis, Medicine, Apoptosis +6