Mechanism and inhibition of the papain‐like protease, PLpro, of SARS‐CoV‐2

Theresa Klemm, Gregor Ebert, Dale J. Calleja, +26

The EMBO Journal

Protein FunctionBiochemistryNatural SciencesMolecular BiologyPapain‐like Protease +1

TBK1 and IKKε Act Redundantly to Mediate STING-Induced NF-κB Responses in Myeloid Cells

Katherine R. Balka, Cynthia Louis, Tahnee L. Saunders, +13

Cell Reports

Inflammatory Lung DiseaseInnate Immune SystemImmunologyImmune RegulationImmunologic Mechanism +28

Protein kinase R is an innate immune sensor of proteotoxic stress via accumulation of cytoplasmic IL-24

Sophia Davidson, Chien‐Hsiung Yu, Annemarie Steiner, +23

Science Immunology

Inflammatory Lung DiseaseInnate Immune SystemImmunologyImmune RegulationCell Death +25

Insights Into Drug Repurposing, as Well as Specificity and Compound Properties of Piperidine-Based SARS-CoV-2 PLpro Inhibitors

Dale J. Calleja, Nathan W. Kuchel, Bernadine G.C. Lu, +22

Frontiers in Chemistry

Discovery of an exosite on the SOCS2-SH2 domain that enhances SH2 binding to phosphorylated ligands

Edmond M. Linossi, Kunlun Li, Gianluca Veggiani, +12

Nature Communications

A novel PLpro inhibitor improves outcomes in a pre-clinical model of long COVID

Stefanie M. Bader, Dale J. Calleja, Shane M. Devine, +40

Nature Communications

NLRP1 variant M1184V decreases inflammasome activation in the context of DPP9 inhibition and asthma severity

Jonas Moecking, Pawat Laohamonthonkul, Katelyn Chalker, +17

Journal of Allergy and Clinical Immunology

Characterisation of the OTU domain deubiquitinase complement of<i>Toxoplasma gondii</i>

Mary‐Louise Wilde, Ushma Ruparel, Theresa Klemm, +4

Life Science Alliance

Mechanism and inhibition of SARS-CoV-2 PLpro

Theresa Klemm, Gregor Ebert, Dale J. Calleja, +25

Plpro BoundSars2 PlproMedicineImmunologyViral Pathogenesis +11

Mutational profiling of SARS-CoV-2 papain-like protease reveals requirements for function, structure, and drug escape

Xinyu Wu, Margareta Go, Julie V. Nguyen, +10

Nature Communications

Mutational ProfilingProtein AssemblyMolecular BiologyDrug EscapeViral Structural Protein +14