Philip Butler

The Metabolism and Toxicity of Furosemide in the Wistar Rat and CD-1 Mouse: a Chemical and Biochemical Definition of the Toxicophore

Dominic P. Williams, Daniel J. Antoine, Philip Butler et al. · Journal of Pharmacology and Experimental Therapeutics · 2007 · 71 citations

Mechanistic in vitro studies confirm that inhibition of the renal apical efflux transporter multidrug and toxin extrusion (<scp>MATE</scp>) 1, and not altered absorption, underlies the increased metformin exposure observed in clinical interactions with cimetidine, trimethoprim or pyrimethamine

Robert Elsby, Stephen Chidlaw, Samuel Outteridge et al. · Pharmacology Research & Perspectives · 2017 · 46 citations · Full text

Development of a transactivator in hepatoma cells that allows expression of phase I, phase II, and chemical defense genes

Christopher E. Goldring, Neil R. Kitteringham, Rosalind E. Jenkins et al. · American Journal of Physiology-Cell Physiology · 2005 · 40 citations

Metabolic Hydrolysis of Aromatic Amides in Selected Rat, Minipig, and Human In Vitro Systems

Peter R. Bradshaw, Ian D. Wilson, Rachel Upcott Gill et al. · Scientific Reports · 2018 · 22 citations · Full text

Mechanistic In Vitro Studies Indicate that the Clinical Drug-Drug Interaction between Telithromycin and Simvastatin Acid Is Driven by Time-Dependent Inhibition of CYP3A4 with Minimal Effect on OATP1B1

Robert Elsby, Victoria Hare, Hannah Neal et al. · Drug Metabolism and Disposition · 2018 · 17 citations · Full text