Metabolic Hydrolysis of Aromatic Amides in Selected Rat, Minipig, and Human In Vitro Systems

Carcinogens are Mutagens: A Simple Test System Combining Liver Homogenates for Activation and Bacteria for Detection

Bruce N. Ames, William E. Durston, Edith F. Yamasaki et al. · Proceedings of the National Academy of Sciences · 1973 · 2.3K citations · Full text

Genetics, Pathology, Molecular Biology +16

Lidocaine metabolism in human liver microsomes by cytochrome P450IIIA4

Mario Bargetzi, Toshifumi Aoyama, Frank J. Gonzalez et al. · Clinical Pharmacology & Therapeutics · 1989 · 264 citations

THE TISSUE DISTRIBUTION, METABOLISM AND EXCRETION OF LIDOCAINE IN RATS, GUINEA PIGS, DOGS AND MAN

J.B. Keenaghan, R N Boyes · Journal of Pharmacology and Experimental Therapeutics · 1972 · 203 citations

Strategy for genotoxicity testing—Metabolic considerations

Warren W. Ku, Anita Bigger, Giovanni Brambilla et al. · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · 2006 · 111 citations

Medicine, Toxicology Testing, Genotoxicity Testing—metabolic Considerations +4

The pharmacokinetics of flutamide and its major metabolites after a single oral dose and during chronic treatment

Martin Schulz, A. Schmoldt, F. Donn et al. · European Journal of Clinical Pharmacology · 1988 · 104 citations

Pharmacological Study, Pharmacology, Toxicology +6