R. Paul Nobrega

Deamidation and isomerization liability analysis of 131 clinical-stage antibodies

Xiaojun Lu, R. Paul Nobrega, Heather Lynaugh et al. · mAbs · 2018 · 148 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmaceutics +17

Clusters of isoleucine, leucine, and valine side chains define cores of stability in high‐energy states of globular proteins: Sequence determinants of structure and stability

Sagar V. Kathuria, Yvonne Chan, R. Paul Nobrega et al. · Protein Science · 2015 · 89 citations · Full text

Life Sciences, Biochemistry, Biophysics +17

Sub-millisecond time-resolved SAXS using a continuous-flow mixer and X-ray microbeam

Rita Graceffa, R. Paul Nobrega, Raúl A. Barrea et al. · Journal of Synchrotron Radiation · 2013 · 72 citations · Full text

Engineering, Biophysics, Microfabrication +12

Rapid assessment of oxidation via middle-down LCMS correlates with methionine side-chain solvent-accessible surface area for 121 clinical stage monoclonal antibodies

Rong Yang, Tushar Jain, Heather Lynaugh et al. · mAbs · 2017 · 67 citations · Full text

Pharmacy, Biochemistry, Antibody Engineering +16

Microsecond Barrier-Limited Chain Collapse Observed by Time-Resolved FRET and SAXS

Sagar V. Kathuria, Can Kayatekin, Raúl A. Barrea et al. · Journal of Molecular Biology · 2014 · 49 citations · Full text

Natural Sciences, Biophysics, Physics +7