John Szpyt

Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1

Evanna L. Mills, Dylan G. Ryan, Hiran A. Prag et al. · Nature · 2018 · 1.7K citations · Full text

Inflammation, Reductive Stress, Anti-inflammatory +10

Architecture of the human interactome defines protein communities and disease networks

Edward L. Huttlin, Raphael J. Bruckner, João A. Paulo et al. · Nature · 2017 · 1.5K citations · Full text

The BioPlex Network: A Systematic Exploration of the Human Interactome

Edward L. Huttlin, Lily Ting, Raphael J. Bruckner et al. · Cell · 2015 · 1.5K citations · Full text

Bioinformatics, Engineering, Interactomics +11

Quantitative Proteomics of the Cancer Cell Line Encyclopedia

David P. Nusinow, John Szpyt, Mahmoud Ghandi et al. · Cell · 2020 · 1K citations · Full text

Proteomic Technology, Medicine, Cancer Genomics +6

Dual proteome-scale networks reveal cell-specific remodeling of the human interactome

Edward L. Huttlin, Raphael J. Bruckner, José Navarrete-Perea et al. · Cell · 2021 · 947 citations · Full text

Signal Transduction, Dual Proteome-scale Networks, Cell Division +12