Christof Gerlach

On the Art of Compiling and Using 'Drug‐Like' Chemical Fragment Spaces

Jörg Degen, Christof Gerlach, Andrea Zaliani et al. · ChemMedChem · 2008 · 573 citations

Combinatorial Chemistry, Using 'Drug‐like, Bioorganic Chemistry +16

More than a Simple Lipophilic Contact: A Detailed Thermodynamic Analysis of Nonbasic Residues in the S1 Pocket of Thrombin

Bernhard Baum, Menshawy Mohamed, Mohamed F. Zayed et al. · Journal of Molecular Biology · 2009 · 130 citations

Protein Chemistry, Proteinlipid Interaction, Protein Assembly +10

Expect the Unexpected or Caveat for Drug Designers: Multiple Structure Determinations Using Aldose Reductase Crystals Treated under Varying Soaking and Co-crystallisation Conditions

H. Steuber, Matthias Zentgraf, Christof Gerlach et al. · Journal of Molecular Biology · 2006 · 108 citations

Aldo-keto Reductase, Biochemistry, Drug Design +13

Congeneric but Still Distinct: How Closely Related Trypsin Ligands Exhibit Different Thermodynamic and Structural Properties

Tobias Brandt, Nicole Holzmann, Laveena Muley et al. · Journal of Molecular Biology · 2010 · 54 citations · Full text

Protein Chemistry, Structural Properties, Biochemistry +5

Thermodynamic Inhibition Profile of a Cyclopentyl and a Cyclohexyl Derivative towards Thrombin: The Same but for Different Reasons

Christof Gerlach, Michael Smolinski, H. Steuber et al. · Angewandte Chemie International Edition · 2007 · 40 citations

Different Reasons, Thrombosis, Medicinal Chemistry +13