Lorn Kategaya

Potent and selective small-molecule MCL-1 inhibitors demonstrate on-target cancer cell killing activity as single agents and in combination with ABT-263 (navitoclax)

H Zhang, J Chen, Sajid Khan Tahir et al. · Cell Death and Disease · 2015 · 427 citations · Full text

Therapeutic Ligands Antagonize Estrogen Receptor Function by Impairing Its Mobility

Jane Guan, Wei Zhou, Marc Hafner et al. · Cell · 2019 · 215 citations · Full text

Signal Transduction, Endocrine Mechanism, Medicine +8

Werner Syndrome Helicase Is Required for the Survival of Cancer Cells with Microsatellite Instability

Lorn Kategaya, Senthil K. Perumal, Jeffrey H. Hager et al. · iScience · 2019 · 131 citations · Full text

Pathology, Molecular Biology, Microsatellite Instability +19

GDC-9545 (Giredestrant): A Potent and Orally Bioavailable Selective Estrogen Receptor Antagonist and Degrader with an Exceptional Preclinical Profile for ER+ Breast Cancer

Jun Liang, Robert A. Blake, Jae H. Chang et al. · Journal of Medicinal Chemistry · 2021 · 130 citations · Full text

Abstract P5-04-07: GDC-9545: A novel ER antagonist and clinical candidate that combines desirable mechanistic and pre-clinical DMPK attributes

Ciara Metcalfe, Ellen Ingalla, RA Blake et al. · Cancer Research · 2019 · 23 citations

Breast Oncology, Chemoprevention Strategy, Clinical Candidate +22