Motoo Nagane

The Enhanced Tumorigenic Activity of a Mutant Epidermal Growth Factor Receptor Common in Human Cancers Is Mediated by Threshold Levels of Constitutive Tyrosine Phosphorylation and Unattenuated Signaling

Hongyi Huang, Motoo Nagane, Candice K. Klingbeil et al. · Journal of Biological Chemistry · 1997 · 590 citations · Full text

A common mutant epidermal growth factor receptor confers enhanced tumorigenicity on human glioblastoma cells by increasing proliferation and reducing apoptosis.

Motoo Nagane, Frank Coufal, Hong Lin et al. · PubMed · 1996 · 413 citations

Neuro-oncology, U87mg.deltaegfr Cells, Glioma +13

Increased death receptor 5 expression by chemotherapeutic agents in human gliomas causes synergistic cytotoxicity with tumor necrosis factor-related apoptosis-inducing ligand in vitro and in vivo.

Motoo Nagane, Guohua Pan, J J Weddle et al. · PubMed · 2000 · 392 citations

Chemotherapeutic Agents, Neuro-oncology, Tumor Necrosis Factor +14

Drug resistance of human glioblastoma cells conferred by a tumor-specific mutant epidermal growth factor receptor through modulation of Bcl-X _L and caspase-3-like proteases

Motoo Nagane, Alexander Levitzki, Aviv Gazit et al. · Proceedings of the National Academy of Sciences · 1998 · 350 citations

Suppression of glioblastoma angiogenicity and tumorigenicity by inhibition of endogenous expression of vascular endothelial growth factor.

Shi‐Yuan Cheng, Hui Huang, Motoo Nagane et al. · Proceedings of the National Academy of Sciences · 1996 · 347 citations · Full text

Pathology, Vegf Secretion, Endogenous Expression +18