Synthesis and biological evaluation of cyclic endomorphin-2 analogs

Renata Perlikowska, Jean Claude do-Rego, Aurore Cravezic, +4

Peptides

Bioorganic ChemistryCyclic Endomorphin-2 AnalogsPharmacologyEnantioselective SynthesisNatural Product Synthesis

Biological activity of endomorphin and [Dmt1]endomorphin analogs with six-membered proline surrogates in position 2

Renata Perlikowska, Katarzyna Gach, Jakub Fichna, +4

Bioorganic & Medicinal Chemistry

Biological ActivityMolecular PharmacologySignal TransductionFunctional SelectivityPosition 2 +7

Synthesis of mixed MOR/KOR efficacy cyclic opioid peptide analogs with antinociceptive activity after systemic administration

Renata Perlikowska, Justyna Piekielna‐Ciesielska, Luca Gentilucci, +7

European Journal of Medicinal Chemistry

Health SciencesPain MedicineMedicinePostoperative Pain ManagementNeuropharmacology +11

Effect of 2′,6′-dimethyl-l-tyrosine (Dmt) on pharmacological activity of cyclic endomorphin-2 and morphiceptin analogs

Jakub Fichna, Renata Perlikowska, Anna Wyrębska, +7

Bioorganic & Medicinal Chemistry

Molecular PharmacologyBiochemistryMedicinePharmacological ActivityMechanism Of Action +5

Pharmacological characterization of endomorphin-2-based cyclic pentapeptides with methylated phenylalanine residues

Renata Perlikowska, Davide Malfacini, Maria Camilla Cerlesi, +8

Peptides

Molecular PharmacologyMethylated Phenylalanine ResiduesBiochemistryMedicineNatural Sciences +6

Design, Synthesis and Pharmacological Characterization of Endomorphin Analogues with Non‐Cyclic Amino Acid Residues in Position 2

Renata Perlikowska, Jakub Fichna, Anna Wyrębska, +6

Basic & Clinical Pharmacology & Toxicology

Pharmacological CharacterizationEndomorphin AnaloguesDegradation RatesPharmacotherapyEm-2 Analogues +18

Synthesis of Mixed Opioid Affinity Cyclic Endomorphin-2 Analogues with Fluorinated Phenylalanines

Justyna Piekielna‐Ciesielska, Renata Perlikowska, Jean Claude do-Rego, +7

ACS Medicinal Chemistry Letters

Novel endomorphin analogues with antagonist activity at the mu-opioid receptor in the gastrointestinal tract

Jakub Fichna, Katarzyna Gach, Renata Perlikowska, +5

Regulatory Peptides

Molecular PharmacologyFunctional SelectivityGastrointestinal PharmacologyMedicinePhysiology +9

Novel glycosylated endomorphin-2 analog produces potent centrally-mediated antinociception in mice after peripheral administration

Jakub Fichna, Marzena Mazur, Daria Grzywacz, +9

Bioorganic & Medicinal Chemistry Letters

Peripheral AdministrationHealth SciencesPain MedicineMedicinePhysiology +11

Antinociceptive and antidepressant-like action of endomorphin-2 analogs with proline surrogates in position 2

Renata Perlikowska, Justyna Piekielna‐Ciesielska, Marzena Mazur, +7

Bioorganic & Medicinal Chemistry

Medicinal ChemistryEndomorphin-2 AnalogsPain MedicinePosition 2Medicine +10