In vivo gene editing in dystrophic mouse muscle and muscle stem cells

Mohammadsharif Tabebordbar, Kexian Zhu, Jason Cheng, +12

Science

In Vivo Gene TherapyMolecular BiologyRegenerative MedicineSkeletal MuscleDmd Gene +17

A multifunctional AAV–CRISPR–Cas9 and its host response

Wei Leong Chew, Mohammadsharif Tabebordbar, Jason Cheng, +6

Nature Methods

Multifunctional Aav–crispr–cas9Natural SciencesGenetic EngineeringMolecular BiologyGenome Engineering +4

Programmable C:G to G:C genome editing with CRISPR-Cas9-directed base excision repair proteins

Liwei Chen, Jung Eun Park, Peter Paa, +5

Nature Communications

Coding and non-coding roles of MOCCI (C15ORF48) coordinate to regulate host inflammation and immunity

Cheryl Lee, Baptiste Kerouanton, Sonia Chothani, +16

Nature Communications

Host InflammationInnate Immune SystemImmunologyImmune RegulationNon-coding Roles +18

TRPV4-Mediated Calcium Influx into Human Bronchial Epithelia upon Exposure to Diesel Exhaust Particles

Jinju Li, Patrick Kanju, Michael Patterson, +7

Environmental Health Perspectives

Immune-orthogonal orthologues of AAV capsids and of Cas9 circumvent the immune response to the administration of gene therapy

Ana M. Moreno, Nathan Palmer, Fernando Alemán, +6

Nature Biomedical Engineering

AllergyAdaptive Immune SystemAav CapsidsImmunologyAntiviral Response +4

Insulin-Like Growth Factor 1 Receptor-Dependent Pathway Drives Epicardial Adipose Tissue Formation After Myocardial Injury

Lior Zangi, Marcela S. Oliveira, Lillian Y. Ye, +12

Circulation

Disrupting the LINC complex by AAV mediated gene transduction prevents progression of Lamin induced cardiomyopathy

Ruth Jinfen Chai, Hendrikje Werner, Peter Yiqing Li, +22

Nature Communications

Engineering and optimising deaminase fusions for genome editing

Luhan Yang, Adrian W. Briggs, Wei Leong Chew, +10

Nature Communications

EngineeringIn Vivo Gene TherapyMolecular BiologyEscherichia ColiPrecise Editing +14

Redox-Responsive Phase-Separating Peptide as a Universal Delivery Vehicle for CRISPR/Cas9 Genome Editing Machinery

Yue Sun, Xiaojie Xu, Liwei Chen, +3

ACS Nano

Redox-responsive Phase-separating PeptideLiquid-liquid Phase SeparationEngineeringGenome SurgeryMedicine +12