Germline BAP1 mutations predispose to malignant mesothelioma

Joseph R. Testa, Mitchell Cheung, Jianming Pei, +16

Nature Genetics

MedicineGermline Bap1 MutationsPathologyCancer Genetics

Germline Mutation of <i>Bap1</i> Accelerates Development of Asbestos-Induced Malignant Mesothelioma

Jinfei Xu, Yuwaraj Kadariya, Mitchell Cheung, +11

Cancer Research

Bap1 Is a Bona Fide Tumor Suppressor: Genetic Evidence from Mouse Models Carrying Heterozygous Germline <i>Bap1</i> Mutations

Yuwaraj Kadariya, Mitchell Cheung, Jinfei Xu, +7

Cancer Research

Cancer SusceptibilityTumor BiologySomatic VariantAsbestos ExposureTumor Heterogeneity +12

Somatic Epigenetic Silencing of <i>RIPK3</i> Inactivates Necroptosis and Contributes to Chemoresistance in Malignant Mesothelioma

Yinfei Tan, Eleonora Sementino, Mitchell Cheung, +12

Clinical Cancer Research

Inactivation of <i>Bap1</i> Cooperates with Losses of <i>Nf2</i> and <i>Cdkn2a</i> to Drive the Development of Pleural Malignant Mesothelioma in Conditional Mouse Models

Anna-Mariya Kukuyan, Eleonora Sementino, Yuwaraj Kadariya, +9

Cancer Research

Group I p21-Activated Kinases (PAKs) Promote Tumor Cell Proliferation and Survival through the AKT1 and Raf–MAPK Pathways

Craig W. Menges, Eleonora Sementino, Jacqueline Talarchek, +4

Molecular Cancer Research

PathologyCancer BiologyTumor BiologyReceptor Tyrosine KinaseCancer Cell Biology +14

BAP1 maintains HIF-dependent interferon beta induction to suppress tumor growth in clear cell renal cell carcinoma

Lauren Langbein, Rayan El Hajjar, He Shen, +8

Cancer Letters

Brca1-associated Protein 1ImmunologyRenal InflammationInterferon GenesCancer Biology +15

Inactivation of <i>Tp53</i> and <i>Pten</i> drives rapid development of pleural and peritoneal malignant mesotheliomas

Eleonora Sementino, Craig W. Menges, Yuwaraj Kadariya, +8

Journal of Cellular Physiology

Novel<i>LRRK2</i>mutations and other rare, non-<i>BAP1</i>-related candidate tumor predisposition gene variants in high-risk cancer families with mesothelioma and other tumors

Mitchell Cheung, Yuwaraj Kadariya, Eleonora Sementino, +5

Human Molecular Genetics

Tumor BiologySomatic VariantTumor HeterogeneityMm Cell LinesGenetics +13

Co-targeting of Akt and Myc inhibits viability of lymphoma cells from Lck-Dlx5 mice

Yinfei Tan, Eleonora Sementino, Jianming Pei, +3

Cancer Biology & Therapy

Lymphocyte DevelopmentImmunologyImmune RegulationTumor BiologyCell Regulation +15