Takahiko Imai

Intracellular Fe2+ accumulation in endothelial cells and pericytes induces blood-brain barrier dysfunction in secondary brain injury after brain hemorrhage

Takahiko Imai, Sena Iwata, Tasuku Hirayama et al. · Scientific Reports · 2019 · 89 citations · Full text

Diabetes Mellitus Aggravates Hemorrhagic Transformation after Ischemic Stroke via Mitochondrial Defects Leading to Endothelial Apoptosis

Keisuke Mishiro, Takahiko Imai, Sou Sugitani et al. · PLoS ONE · 2014 · 66 citations · Full text

Vascular Disease, Mitochondrial Dysfunction, Cell Death +23

Cilostazol ameliorates collagenase-induced cerebral hemorrhage by protecting the blood–brain barrier

Toshinori Takagi, Takahiko Imai, Keisuke Mishiro et al. · Journal of Cerebral Blood Flow & Metabolism · 2015 · 57 citations · Full text

Antiplatelet Drugs, Blood-brain Barrier Permeability, Neurovascular Disease +18

A multi-laboratory preclinical trial in rodents to assess treatment candidates for acute ischemic stroke

Patrick D. Lyden, Márcio A. Diniz, Francesca Bosetti et al. · Science Translational Medicine · 2023 · 57 citations

Cerebrovascular Disease, Cerebral Vascular Regulation, Thrombosis +19

A novel nuclear factor erythroid 2-related factor 2 (Nrf2) activator RS9 attenuates brain injury after ischemia reperfusion in mice

Keita Yamauchi, Yusuke Nakano, Takahiko Imai et al. · Neuroscience · 2016 · 46 citations · Full text

Ischemia Reperfusion, Cell Death, Cerebral Vascular Regulation +16