The growth factor progranulin attenuates neuronal injury induced by cerebral ischemia-reperfusion through the suppression of neutrophil recruitment

Yusuke Egashira, Yukiya Suzuki, Yukio Azuma, +9

Journal of Neuroinflammation

Involvement of Mincle and Syk in the changes to innate immunity after ischemic stroke

Yukiya Suzuki, Yusuke Nakano, Keisuke Mishiro, +6

Scientific Reports

ImmunologyCell DeathCerebrovascular DiseaseInnate ImmunityImmune System +23

Pharmacological inhibition of TLR4-NOX4 signal protects against neuronal death in transient focal ischemia

Yukiya Suzuki, Kozo Hattori, Junya Hamanaka, +13

Scientific Reports

Phosphodiesterase-III Inhibitor Prevents Hemorrhagic Transformation Induced by Focal Cerebral Ischemia in Mice Treated with tPA

Mitsunori Ishiguro, Keisuke Mishiro, Yasuyuki Fujiwara, +8

PLoS ONE

Combined TpaCerebrovascular DiseasePharmacotherapyFocal Cerebral IschemiaCerebral Vascular Regulation +20

The conditioned medium of murine and human adipose-derived stem cells exerts neuroprotective effects against experimental stroke model

Yusuke Egashira, Sou Sugitani, Yukiya Suzuki, +6

Brain Research

Social SciencesExperimental Stroke ModelCerebral Vascular RegulationRegenerative MedicineNeuroregeneration +14

Diabetes Mellitus Aggravates Hemorrhagic Transformation after Ischemic Stroke via Mitochondrial Defects Leading to Endothelial Apoptosis

Keisuke Mishiro, Takahiko Imai, Sou Sugitani, +8

PLoS ONE

Vascular DiseaseMitochondrial DysfunctionCell DeathPathologyMitochondrial Defects Leading +21

A broad-spectrum matrix metalloproteinase inhibitor prevents hemorrhagic complications induced by tissue plasminogen activator in mice

Keisuke Mishiro, Mitsunori Ishiguro, Yukiya Suzuki, +3

Neuroscience

InflammationThrombosisHematologyEndothelial DysfunctionPathology +9

A Rho kinase (ROCK) inhibitor, fasudil, prevents matrix metalloproteinase-9-related hemorrhagic transformation in mice treated with tissue plasminogen activator

Mitsunori Ishiguro, Koh Kawasaki, Yukiya Suzuki, +9

Neuroscience

AngiogenesisRho KinaseHematologyPathologyHemostasis +9

Cilostazol ameliorates collagenase-induced cerebral hemorrhage by protecting the blood–brain barrier

Toshinori Takagi, Takahiko Imai, Keisuke Mishiro, +11

Journal of Cerebral Blood Flow & Metabolism

Antiplatelet DrugsBlood-brain Barrier PermeabilityNeurovascular DiseaseCerebral Vascular RegulationInflammation +16

Cilostazol Ameliorates Warfarin-Induced Hemorrhagic Transformation After Cerebral Ischemia in Mice

Akira Kitashoji, Yusuke Egashira, Keisuke Mishiro, +5

Stroke