Yingsi Chen

Discovery of [4-Amino-2-(1-methanesulfonylpiperidin-4-ylamino)pyrimidin-5-yl](2,3-difluoro-6- methoxyphenyl)methanone (R547), A Potent and Selective Cyclin-Dependent Kinase Inhibitor with Significant in Vivo Antitumor Activity

Xin‐Jie Chu, Wanda DePinto, David Bartkovitz et al. · Journal of Medicinal Chemistry · 2006 · 116 citations · Full text

Drug Target, Pharmacotherapy, Cell Cycle +17

<i>In vitro</i> and <i>in vivo</i> activity of R547: a potent and selective cyclin-dependent kinase inhibitor currently in phase I clinical trials

Wanda DePinto, Xin‐Jie Chu, Xuefeng Yin et al. · Molecular Cancer Therapeutics · 2006 · 102 citations · Full text

Molecular Pharmacology, Tumor Biology, Cell Cycle Block +15

Synthesis and activity of quinolinyl-methylene-thiazolinones as potent and selective cyclin-dependent kinase 1 inhibitors

Shaoqing Chen, Li Chen, Nam T. Le et al. · Bioorganic & Medicinal Chemistry Letters · 2007 · 54 citations · Full text

Medicinal Chemistry, Heterocyclic, Biochemistry +9

Discovery of Orally Active Carboxylic Acid Derivatives of 2-Phenyl-5-trifluoromethyloxazole-4-carboxamide as Potent Diacylglycerol Acyltransferase-1 Inhibitors for the Potential Treatment of Obesity and Diabetes

Yimin Qian, Stanley J. Wertheimer, Mushtaq Ahmad et al. · Journal of Medicinal Chemistry · 2011 · 41 citations · Full text

Lipid Analysis, Pharmacotherapy, Glucose Tolerance +20

Identification of novel, potent and selective inhibitors of Polo-like kinase 1

Shaoqing Chen, David Bartkovitz, Jianping Cai et al. · Bioorganic & Medicinal Chemistry Letters · 2011 · 33 citations

Signaling Pathway, Medicine, Receptor Tyrosine Kinase +9