Concepedia

Synthesis and activity of quinolinyl-methylene-thiazolinones as potent and selective cyclin-dependent kinase 1 inhibitors

Shaoqing Chen, Li Chen, Nam T. Le, Chunlin Zhao, Achyutharao Sidduri, Jian Ping Lou, Christophe Michoud, Louis Portland, Nicole M. Jackson, Jinjun Liu,

Bioorganic & Medicinal Chemistry Letters · 2007 · 54 citations · 10 references

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Selective small-molecule inhibitor reveals critical mitotic functions of human CDK1

Lyubomir T. Vassilev, Christian Tovar, Shaoqing Chen et al. · Proceedings of the National Academy of Sciences · 2006 · 824 citations · Full text

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Cyclin-dependent kinase 2 is essential for meiosis but not for mitotic cell division in mice

Sagrario Ortega, Ignacio Priéto, Junko Odajima et al. · Nature Genetics · 2003 · 793 citations

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Cdk2 Knockout Mice Are Viable

Cyril Berthet, Eiman Aleem, Vincenzo Coppola et al. · Current Biology · 2003 · 657 citations · Full text

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Proliferation of cancer cells despite CDK2 inhibition

Osamu Tetsu, Frank McCormick · Cancer Cell · 2003 · 467 citations · Full text

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Discovery of [4-Amino-2-(1-methanesulfonylpiperidin-4-ylamino)pyrimidin-5-yl](2,3-difluoro-6- methoxyphenyl)methanone (R547), A Potent and Selective Cyclin-Dependent Kinase Inhibitor with Significant in Vivo Antitumor Activity

Xin‐Jie Chu, Wanda DePinto, David Bartkovitz et al. · Journal of Medicinal Chemistry · 2006 · 118 citations · Full text

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