Discovery of a Novel Oral Glucocorticoid Receptor Modulator (AZD9567) with Improved Side Effect Profile

Lena Ripa, K. A. P. Edman, Matthew Dearman, +21

Journal of Medicinal Chemistry

ImmunologyPharmacotherapyGlucocorticoidInflammatory ArthritisInflammation +17

Benzoxazepines Achieve Potent Suppression of IL‐17 Release in Human T‐Helper 17 (T_H17) Cells through an Induced‐Fit Binding Mode to the Nuclear Receptor RORγ

Roine I. Olsson, Yafeng Xue, Stefan von Berg, +13

ChemMedChem

Potent and Orally Bioavailable Inverse Agonists of RORγt Resulting from Structure-Based Design

Frank Narjes, Yafeng Xue, Stefan von Berg, +19

Journal of Medicinal Chemistry

Drug TargetRetinoic Acid ReceptorPeptide SciencePharmacotherapyChemical Biology +17

Synthesis and evaluation of diphenylphosphinic amides and diphenylphosphine oxides as inhibitors of Kv1.5

Roine I. Olsson, Ingemar Jacobson, Jonas Boström, +20

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryDerivative (Chemistry)Natural SciencesMedicineDiphenylphosphine Oxides +7

Novel thioamide derivatives as neutral CB1 receptor antagonists

Jonas Boström, Roine I. Olsson, Joakim Tholander, +5

Bioorganic & Medicinal Chemistry Letters

Functional SelectivityMedicinePharmacological AgentPharmacotherapyNovel Thioamide Derivatives +2

AZD0284, a Potent, Selective, and Orally Bioavailable Inverse Agonist of Retinoic Acid Receptor-Related Orphan Receptor C2

Frank Narjes, Antonio Llinàs, Stefan von Berg, +24

Journal of Medicinal Chemistry

Isoindolinone compounds active as Kv1.5 blockers identified using a multicomponent reaction approach

Johan Kajanus, Ingemar Jacobson, Annika Åstrand, +16

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryBiochemistryNatural SciencesOrganic ChemistryChemistry +3

Composition of the activated complex in the stereoselective deprotonation of cyclohexene oxide by a chiral lithium amide

Roine I. Olsson, Per Ahlberg

Tetrahedron Asymmetry

Cyclohexene OxideChemical EngineeringEnantioselective SynthesisEngineeringActivated Complex +5

Discovery of Potent and Orally Bioavailable Inverse Agonists of the Retinoic Acid Receptor-Related Orphan Receptor C2

Stefan von Berg, Yafeng Xue, Mia Collins, +18

ACS Medicinal Chemistry Letters

Medicinal ChemistrySignal TransductionG Protein-coupled ReceptorMedicineInverse Agonists +11

Lactam sulfonamides as potent inhibitors of the Kv1.5 potassium ion channel

Roine I. Olsson, Ingemar Jacobson, Tommy Iliefski, +23

Bioorganic & Medicinal Chemistry Letters