Jonathan A. Pachter

Targeting focal adhesion kinase renders pancreatic cancers responsive to checkpoint immunotherapy

Hong Jiang, Samarth Hegde, Brett L. Knolhoff et al. · Nature Medicine · 2016 · 1K citations · Full text

Medicine, Cancer Biology, Oncology +10

Nuclear FAK Controls Chemokine Transcription, Tregs, and Evasion of Anti-tumor Immunity

Alan Serrels, Tom Lund, Bryan Serrels et al. · Cell · 2015 · 417 citations · Full text

Medicine, Immunology, Oncology +17

Merlin Deficiency Predicts FAK Inhibitor Sensitivity: A Synthetic Lethal Relationship

Irina M. Shapiro, Vihren N. Kolev, Christian M. Vidal et al. · Science Translational Medicine · 2014 · 244 citations

Medicine, Oncology, Pharmacology +17

A Platform of Synthetic Lethal Gene Interaction Networks Reveals that the GNAQ Uveal Melanoma Oncogene Controls the Hippo Pathway through FAK

Xiaodong Feng, Nadia Arang, Damiano Cosimo Rigiracciolo et al. · Cancer Cell · 2019 · 243 citations · Full text

Medicine, Genetics, Molecular Biology +14

Compensatory Insulin Receptor (IR) Activation on Inhibition of Insulin-Like Growth Factor-1 Receptor (IGF-1R): Rationale for Cotargeting IGF-1R and IR in Cancer

Elizabeth Buck, Prafulla C. Gokhale, Susan Koujak et al. · Molecular Cancer Therapeutics · 2010 · 218 citations

Medicine, Oncology, Pharmacology +17