Dirk Scharn

Chemically Induced Degradation of the Oncogenic Transcription Factor BCL6

Nina Kerres, Steffen Steurer, Stefanie Schlager et al. · Cell Reports · 2017 · 206 citations · Full text

Medicine, Cancer Biology, Molecular Biology +11

Start Selective and Rigidify: The Discovery Path toward a Next Generation of EGFR Tyrosine Kinase Inhibitors

Harald Engelhardt, Dietrich Böse, Mark Petronczki et al. · Journal of Medicinal Chemistry · 2019 · 145 citations · Full text

Medicine, Oncology, Pharmacology +17

The novel BET bromodomain inhibitor BI 894999 represses super-enhancer-associated transcription and synergizes with CDK9 inhibition in AML

Daniel Gerlach, Ulrike Tontsch-Grunt, Anke Baum et al. · Oncogene · 2018 · 83 citations · Full text

Medicine, Oncology, Pharmacology +14

Selective and Potent CDK8/19 Inhibitors Enhance NK-Cell Activity and Promote Tumor Surveillance

Marco H. Hofmann, Rajeswaran Mani, Harald Engelhardt et al. · Molecular Cancer Therapeutics · 2020 · 72 citations · Full text

Life Sciences, Immunology, Oncology +17

Discovery and Structure-Based Optimization of Benzimidazole-Derived Activators of SOS1-Mediated Nucleotide Exchange on RAS

Timothy R. Hodges, Jason R. Abbott, Andrew J. Little et al. · Journal of Medicinal Chemistry · 2018 · 56 citations · Full text

Life Sciences, Medicinal Chemistry, Molecular Biology +16