Nobuko Koshikawa

ROS-Generating Mitochondrial DNA Mutations Can Regulate Tumor Cell Metastasis

Kaori Ishikawa, Keizo Takenaga, Miho Akimoto et al. · Science · 2008 · 1.5K citations · Full text

Medicine, Cancer Biology, Oncology +13

Reactive Oxygen Species-generating Mitochondrial DNA Mutation Up-regulates Hypoxia-inducible Factor-1α Gene Transcription via Phosphatidylinositol 3-Kinase-Akt/Protein Kinase C/Histone Deacetylase Pathway

Nobuko Koshikawa, Jun‐Ichi Hayashi, Akira Nakagawara et al. · Journal of Biological Chemistry · 2009 · 146 citations · Full text

Life Sciences, Cell Biology, Genetics +17

Inhibition of KRAS codon 12 mutants using a novel DNA-alkylating pyrrole–imidazole polyamide conjugate

Kiriko Hiraoka, Takahiro Inoue, Rhys Dylan Taylor et al. · Nature Communications · 2015 · 103 citations · Full text

Medicine, Oncology, Pharmacology +17

Therapeutic efficacy of the suicide gene driven by the promoter of vascular endothelial growth factor gene against hypoxic tumor cells.

Nobuko Koshikawa, Keizo Takenaga, Michito Tagawa et al. · PubMed · 2000 · 88 citations

Medicine, Cancer Biology, Oncology +16

3-Methyladenine suppresses cell migration and invasion of HT1080 fibrosarcoma cells through inhibiting phosphoinositide 3-kinases independently of autophagy inhibition

Shingo Ito, Nobuko Koshikawa, S Mochizuki et al. · International Journal of Oncology · 2007 · 76 citations · Full text

Life Sciences, Cell Biology, Oncology +15