ROS-Generating Mitochondrial DNA Mutations Can Regulate Tumor Cell Metastasis

Kaori Ishikawa, Keizo Takenaga, Miho Akimoto, +6

Science

Immune evasion through mitochondrial transfer in the tumour microenvironment

Hideki Ikeda, Katsushige Kawase, Tatsuya Nishi, +32

Nature

Binding of pEL98 protein, an S100-related calcium-binding protein, to nonmuscle tropomyosin

Keizo Takenaga, Yohko Nakamura, S Sakiyama, +3

The Journal of Cell Biology

Molecular BiologyCytoskeletonS100-related Calcium-binding ProteinCellular PhysiologyProtein Synthesis +21

Expression of antisense RNA to S100A4 gene encoding an S100-related calcium-binding protein suppresses metastatic potential of high-metastatic Lewis lung carcinoma cells

Keizo Takenaga, Yohko Nakamura, Shigeru Sakiyama

Oncogene

Antisense RnaMedicineS100a4 GeneCell BiologyTumor Suppressor +5

Reactive Oxygen Species-generating Mitochondrial DNA Mutation Up-regulates Hypoxia-inducible Factor-1α Gene Transcription via Phosphatidylinositol 3-Kinase-Akt/Protein Kinase C/Histone Deacetylase Pathway

Nobuko Koshikawa, Jun‐Ichi Hayashi, Akira Nakagawara, +1

Journal of Biological Chemistry

GeneticsMitochondrial BiologyHdac ActivityCancer BiologyRedox Biology +15

Increased expression of S100A4, a metastasis-associated gene, in human colorectal adenocarcinomas.

Keizo Takenaga, Hirofumi Nakanishi, Kyoko Wada, +4

PubMed

Tumor BiologyMetastasis-associated GeneHuman Colorectal AdenocarcinomasMedicineS100a4 Gene +11

Induction of differentiation of cultured human promyelocytic leukemia cells by retinoids

Yoshio Honma, Keizo Takenaga, Takashi Kasukabe, +1

Biochemical and Biophysical Research Communications

Developmental BiologyCell RegulationCell DivisionMixed-phenotype Acute LeukemiaCell Culture +4

Mitochondrial DNA Mutations Regulate Metastasis of Human Breast Cancer Cells

Hirotake Imanishi, Keisuke Hattori, Reiko Wada, +5

PLoS ONE

Breast OncologyMitochondrial BiologyReactive Oxygen SpeciesCancer BiologyTumor Biology +17

Hypomethylation of the metastasis-associated S100A4 gene correlates with gene activation in human colon adenocarcinoma cell lines

Naoko Nakamura, Keizo Takenaga

Clinical & Experimental Metastasis

Antidiabetic adiponectin receptor agonist AdipoRon suppresses tumour growth of pancreatic cancer by inducing RIPK1/ERK-dependent necroptosis

Miho Akimoto, Riruke Maruyama, Yasunari Kawabata, +2

Cell Death and Disease