Pharmacological Inhibition of the Wnt Acyltransferase PORCN Prevents Growth of WNT-Driven Mammary Cancer

Kyle David Proffitt, Babita Madan, Zhiyuan Ke, +5

Cancer Research

Wnt addiction of genetically defined cancers reversed by PORCN inhibition

Babita Madan, Zhanbo Ke, Nathan Harmston, +16

Oncogene

Porcn InhibitionPathologyWnt AddictionAvailable Porcn InhibitorTumor Biology +14

Stroma provides an intestinal stem cell niche in the absence of epithelial Wnts

Zahra Kabiri, Gediminas Greicius, Babita Madan, +10

Development

Adult Stem CellCell SpecializationTissue DevelopmentSignaling PathwayEpithelial Wnts +15

SB1518, a novel macrocyclic pyrimidine-based JAK2 inhibitor for the treatment of myeloid and lymphoid malignancies

Stefan Hart, K C Goh, Veronica Novotny‐Diermayr, +15

Leukemia

Isoliquiritigenin inhibits IκB kinase activity and ROS generation to block TNF-α induced expression of cell adhesion molecules on human endothelial cells

Sarvesh Kumar, Amit Sharma, Babita Madan, +2

Biochemical Pharmacology

InflammationSignal TransductionMedicineCell AdhesionImmunology +9

USP6 oncogene promotes Wnt signaling by deubiquitylating Frizzleds

Babita Madan, Matthew P. Walker, Robert Young, +15

Proceedings of the National Academy of Sciences

Transcriptional RegulationSignaling PathwayCell RegulationWnt LigandsMedicine +13

Pacritinib (SB1518), a JAK2/FLT3 inhibitor for the treatment of acute myeloid leukemia

Stefan Hart, K. C. Goh, Veronica Novotny‐Diermayr, +9

Blood Cancer Journal

ImmunologyPharmacotherapyTumor BiologyMyeloid NeoplasiaHematological Malignancy +15

Bone loss from Wnt inhibition mitigated by concurrent alendronate therapy

Babita Madan, Mitchell J. McDonald, Gabrielle E. Foxa, +3

Bone Research

Bone DiseaseBone LossBone HealthMetabolic Bone DiseaseMedicine +12

Impaired function of primitive hematopoietic cells in mice lacking the Mixed-Lineage-Leukemia homolog Mll5

Vikas Madan, Babita Madan, Urszula Brykczynska, +10

Blood

PORCN inhibition synergizes with PI3K/mTOR inhibition in Wnt-addicted cancers

Zheng Zhong, Sugunavathi Sepramaniam, Xin Hui Chew, +4

Oncogene

Porcn InhibitionPorcn InhibitorsCancer BiologyTumor BiologyPancreatic Cancer +15