PHA-739358, a potent inhibitor of Aurora kinases with a selective target inhibition profile relevant to cancer

Patrizia Carpinelli, Roberta Ceruti, Maria Laura Giorgini, +19

Molecular Cancer Therapeutics

Histone H3Potent InhibitorCancer BiologyTumor BiologyDrug Potency +14

A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity

Alessia Montagnoli, Barbara Valsasina, Valter Croci, +23

Nature Chemical Biology

Cell RegulationMedicineCdc7 Kinase InhibitorDna ReplicationCell Cycle +5

Immunohistopathological and neuroimaging characterization of murine orthotopic xenograft models of glioblastoma multiforme recapitulating the most salient features of human disease.

Enrico Radaelli, Roberta Ceruti, Veronica Patton, +8

PubMed

Vimentin ExpressionPathologyCerebral OrganoidHigh-grade GliomasGlioma +24

Vascular Endothelial Growth Factor C Promotes Ovarian Carcinoma Progression through Paracrine and Autocrine Mechanisms

Alessandra Decio, Giulia Taraboletti, Veronica Patton, +6

American Journal Of Pathology

AngiogenesisMedicineAutocrine MechanismsCancer GrowthPathology +8

Phosphorylation of TCTP as a marker for polo-like kinase-1 activity in vivo.

Ulisse Cucchi, Laura Gianellini, Anna De Ponti, +11

PubMed

Molecular RegulationCell DeathPathologyCellular PhysiologyTumor Biology +19

Dual Targeting of CDK and Tropomyosin Receptor Kinase Families by the Oral Inhibitor PHA-848125, an Agent with Broad-Spectrum Antitumor Efficacy

Clara Albanese, Rachele Alzani, Nadia Amboldi, +16

Molecular Cancer Therapeutics

Chemoprevention StrategyRetinoblastoma ProteinTumor BiologyBroad-spectrum Antitumor EfficacyReceptor Tyrosine Kinase +15

Efficacy of PHA-848125, a Cyclin-Dependent Kinase Inhibitor, on the K-RasG12DLA2 Lung Adenocarcinoma Transgenic Mouse Model: Evaluation by Multimodality Imaging

Anna Degrassi, Micaela Russo, Cristina Nanni, +7

Molecular Cancer Therapeutics

The Polo-Like Kinase 1 (PLK1) Inhibitor NMS-P937 Is Effective in a New Model of Disseminated Primary CD56+ Acute Monoblastic Leukaemia

Alessia Casolaro, Josée Golay, Clara Albanese, +15

PLoS ONE

Hematological MalignancyNew ModelMedicineMixed-phenotype Acute LeukemiaMalignant Blood Disorder +13

Therapeutic efficacy of the pan-cdk inhibitor PHA-793887 in vitro and in vivo in engraftment and high-burden leukemia models

Rachele Alzani, Olga Pedrini, Clara Albanese, +9

Experimental Hematology

Hematological MalignancyPan-cdk Inhibitor Pha-793887MedicineImmunologyHigh-burden Leukemia Models +8

Reduced mammary tumor progression in a transgenic mouse model fed an isoflavone‐poor soy protein concentrate

Giulia Chiesa, Elena Rigamonti, Maria Rosa Lovati, +10

Molecular Nutrition & Food Research