PHA-739358, a potent inhibitor of Aurora kinases with a selective target inhibition profile relevant to cancer

Patrizia Carpinelli, Roberta Ceruti, Maria Laura Giorgini, +19

Molecular Cancer Therapeutics

Histone H3Potent InhibitorCancer BiologyTumor BiologyDrug Potency +14

1,4,5,6-Tetrahydropyrrolo[3,4-<i>c</i>]pyrazoles:  Identification of a Potent Aurora Kinase Inhibitor with a Favorable Antitumor Kinase Inhibition Profile

Daniele Fancelli, Jürgen Moll, Mario Varasi, +22

Journal of Medicinal Chemistry

Molecular PharmacologyMedicinal ChemistryChemoprevention StrategyBiochemistryVivo Tumor Models +12

PHA-680632, a Novel Aurora Kinase Inhibitor with Potent Antitumoral Activity

Chiara Soncini, Patrizia Carpinelli, Laura Gianellini, +15

Clinical Cancer Research

Potent and Selective Aurora Inhibitors Identified by the Expansion of a Novel Scaffold for Protein Kinase Inhibition

Daniele Fancelli, Daniela Berta, Simona Bindi, +20

Journal of Medicinal Chemistry

Molecular BiologyChemical BiologyPharmaceutical ChemistryTumor BiologyMedicinal Chemistry +16

Crystal Structure of the T315I Abl Mutant in Complex with the Aurora Kinases Inhibitor PHA-739358

Michèle Modugno, Elena Casale, Chiara Soncini, +9

Cancer Research

Hematological MalignancyTumor BiologyKinase DomainT315i Abl MutantCrystal Structure +13

Phase I Pharmacokinetic and Pharmacodynamic Study of the Aurora Kinase Inhibitor Danusertib in Patients With Advanced or Metastatic Solid Tumors

Neeltje Steeghs, Ferry A.L.M. Eskens, Hans Gelderblom, +9

Journal of Clinical Oncology

Cloning and overexpression in Escherichia coli of the genes encoding NAD-dependent alcohol dehydrogenase from two Sulfolobus species

Raffaele Cannio, Gabriella Fiorentino, Patrizia Carpinelli, +2

Journal of Bacteriology

BiosynthesisEngineeringCellular EnzymologyBiochemistryAldehyde Dehydrogenase +13

A phase I study of danusertib (PHA-739358) in adult patients with accelerated or blastic phase chronic myeloid leukemia and Philadelphia chromosome-positive acute lymphoblastic leukemia resistant or intolerant to imatinib and/or other second generation c-ABL therapy

Gautam Borthakur, Hervé Dombret, Philippe Schafhausen, +9

Haematologica

Analysis of the molecular species generated by mdm2 gene amplification in liposarcomas

Elena Tamborini, Gabriella Della Torre, Cinzia Lavarino, +4

International Journal of Cancer

Suramin modulates cellular levels of hepatocyte growth factor receptor by inducing shedding of a soluble form

Arturo Galvani, Cinzia Cristiani, Patrizia Carpinelli, +2

Biochemical Pharmacology

Molecular PhysiologySignal TransductionHepatologySoluble FormMedicine +6