A CXCL1 Paracrine Network Links Cancer Chemoresistance and Metastasis

Swarnali Acharyya, Thórdur Óskarsson, Sakari Vanharanta, +10

Cell

Tumor BiologyMedicineTumor SuppressorCancer BiologyCell Biology +1

Breast cancer cells produce tenascin C as a metastatic niche component to colonize the lungs

Thórdur Óskarsson, Swarnali Acharyya, Xiang H.-F. Zhang, +7

Nature Medicine

Malignant DiseaseMetastatic Niche ComponentTenascin CMedicineBreast Cancer Cells +9

The common colorectal cancer predisposition SNP rs6983267 at chromosome 8q24 confers potential to enhanced Wnt signaling

Sari Tuupanen, Mikko Turunen, Rainer Lehtonen, +19

Nature Genetics

MedicineGeneticsCancer Cell BiologyPathologyColorectal Cancer +7

Therapy-induced tumour secretomes promote resistance and tumour progression

Anna C. Obenauf, Yilong Zou, Andrew L. Ji, +9

Nature

Therapy-induced Tumour SecretomesMedicineTumor SuppressorCancer BiologyCell Biology +3

Early-Onset Renal Cell Carcinoma as a Novel Extraparaganglial Component of SDHB-Associated Heritable Paraganglioma

Sakari Vanharanta, Mary Buchta, Sarah R. McWhinney, +15

The American Journal of Human Genetics

UrologyTumoral PathologyGenitourinary CancerRenal PathologyPathology +4

Epigenetic expansion of VHL-HIF signal output drives multiorgan metastasis in renal cancer

Sakari Vanharanta, Weiping Shu, Fabienne Brenet, +7

Nature Medicine

UrologyGenitourinary CancerMedicineEpigenetic ExpansionCancer Genomics +4

Transcription Factor PROX1 Induces Colon Cancer Progression by Promoting the Transition from Benign to Highly Dysplastic Phenotype

Tatiana V. Petrova, Antti I. Nykänen, Camilla Norrmén, +15

Cancer Cell

MedicineColorectal CancerPathologyTumor SuppressorGene Expression +5

Acquired resistance to anti-MAPK targeted therapy confers an immune-evasive tumor microenvironment and cross-resistance to immunotherapy in melanoma

Lisa Haas, Anais Elewaut, Camille L. Gérard, +21

Nature Cancer

Therapy ConfersTumor ImmunologyImmune-evasive Tumor MicroenvironmentCancer ImmunosurveillanceMedicine +8

Biallelic Inactivation of Fumarate Hydratase (FH) Occurs in Nonsyndromic Uterine Leiomyomas but Is Rare in Other Tumors

Rainer Lehtonen, Maija Kiuru, Sakari Vanharanta, +18

American Journal Of Pathology

Biallelic InactivationFumarate HydratasePathologyGynecologyMedicine +3

Serrated carcinomas form a subclass of colorectal cancer with distinct molecular basis

Päivi Laiho, Antti Kokko, Sakari Vanharanta, +11

Oncogene

Tumor BiologyCarcinomas FormGastrointestinal OncologyMedicineColorectal Cancer +5