Chemically defined conditions for human iPSC derivation and culture

Guokai Chen, Daniel R. Gulbranson, Zhonggang Hou, +12

Nature Methods

PhysiologyFine ChemicalCell CultureMetabolismHuman Metabolism +2

Epigenomic Analysis of Multilineage Differentiation of Human Embryonic Stem Cells

Wei Xie, Matthew D. Schultz, Ryan Lister, +39

Cell

ChromatinCell LineageDevelopmental BiologyCell SpecializationMedicine +10

Efficient genome engineering in human pluripotent stem cells using Cas9 from <i>Neisseria meningitidis</i>

Zhonggang Hou, Yan Zhang, Nicholas E. Propson, +4

Proceedings of the National Academy of Sciences

EngineeringCrispr-cas MachineryMolecular BiologyStem Cell BiologyCrispr-cas Systems +18

Single-cell RNA-seq reveals novel regulators of human embryonic stem cell differentiation to definitive endoderm

Li‐Fang Chu, Ning Leng, Jue Zhang, +7

Genome biology

Human pluripotent stem cell-derived neural constructs for predicting neural toxicity

Michael P. Schwartz, Zhonggang Hou, Nicholas E. Propson, +12

Proceedings of the National Academy of Sciences

Human Pluripotent StemCerebral OrganoidLinear Support VectorBiomedical EngineeringSocial Sciences +18

Actin-Myosin Contractility Is Responsible for the Reduced Viability of Dissociated Human Embryonic Stem Cells

Guokai Chen, Zhonggang Hou, Daniel R. Gulbranson, +1

Cell stem cell

Developmental BiologyMedicineStem Cell ResearchCell MotilityCytoskeleton +6

Zfx Controls the Self-Renewal of Embryonic and Hematopoietic Stem Cells

José M. Galán-Caridad, Sivan Harel, Teresita L. Arenzana, +4

Cell

Embryonic Stem CellDevelopmental BiologyMedicineStem Cell MobilizationAdult Stem Cell +6

Dynamics of PARKIN-Dependent Mitochondrial Ubiquitylation in Induced Neurons and Model Systems Revealed by Digital Snapshot Proteomics

Alban Ordureau, João A. Paulo, Wei Zhang, +9

Molecular Cell

Mitochondrial FunctionOrganelle DynamicProtein FoldingMedicineNatural Sciences +10

Mammalian Target of Rapamycin Controls Dendritic Cell Development Downstream of Flt3 Ligand Signaling

Taheri Sathaliyawala, William O’Gorman, Melanie Greter, +7

Immunity

Mammalian TargetSignal TransductionSignaling PathwayMolecular PathwayCell Regulation +8

Introducing a Spectrum of Long-Range Genomic Deletions in Human Embryonic Stem Cells Using Type I CRISPR-Cas

Adam Dolan, Zhonggang Hou, Yibei Xiao, +5

Molecular Cell

Off-target EffectMedicineGeneticsGenetic EngineeringStem Cell Research +7