Tanya Hay

Application of PBPK modelling in drug discovery and development at Pfizer

Hannah M. Jones, Maurice Dickins, Kuresh Youdim et al. · Xenobiotica · 2011 · 93 citations

Modulation of the Partition Coefficient between Octanol and Buffer at pH 7.4 and p Ka to Achieve the Optimum Balance of Blood Clearance and Volume of Distribution for a Series of Tetrahydropyran Histamine Type 3 Receptor Antagonists

Tanya Hay, Rhys D.O. Jones, Kevin Beaumont et al. · Drug Metabolism and Disposition · 2009 · 46 citations

Discovery and Optimization of Selective Na _v 1.8 Modulator Series That Demonstrate Efficacy in Preclinical Models of Pain

Sharan K. Bagal, Peter J. Bungay, Stephen M. Denton et al. · ACS Medicinal Chemistry Letters · 2015 · 40 citations · Full text

Clinical Micro-Dose Studies to Explore the Human Pharmacokinetics of Four Selective Inhibitors of Human Nav1.7 Voltage-Dependent Sodium Channels

Hannah M. Jones, Richard P. Butt, Rob Webster et al. · Clinical Pharmacokinetics · 2016 · 36 citations

Four Selective Inhibitors, Human Pharmacokinetics, Physiology +9

Application of a high‐resolution in vitro human MDR1‐MDCK assay and in vivo studies in preclinical species to improve prediction of CNS drug penetration

Licong Jiang, Sanjeev Kumar, Marc Nuechterlein et al. · Pharmacology Research & Perspectives · 2022 · 19 citations · Full text