Brefeldin A's effects on endosomes, lysosomes, and the TGN suggest a general mechanism for regulating organelle structure and membrane traffic

Jennifer Lippincott‐Schwartz, Lydia C. Yuan, Christopher Tipper, +3

Cell

Signal TransductionBrefeldin AOrganelle DynamicCell OrganelleNatural Sciences +13

COPII-Coated Vesicle Formation Reconstituted with Purified Coat Proteins and Chemically Defined Liposomes

Ken Matsuoka, Lelio Orci, M Amherdt, +4

Cell

Purified Coat ProteinsProteinlipid InteractionBiochemistryNatural SciencesMolecular Biology +3

ADP-Ribosylation factor is a subunit of the coat of Golgi-derived COP-coated vesicles: A novel role for a GTP-binding protein

Tito Serafini, Lelio Orci, M Amherdt, +3

Cell

Protein FunctionSignal TransductionAdp-ribosylation FactorBiochemistryGolgi-derived Cop-coated Vesicles +9

Brefeldin A, a drug that blocks secretion, prevents the assembly of non-clathrin-coated buds on Golgi cisternae

Lelio Orcl, Mitsuo Tagaya, M Amherdt, +5

Cell

Protein SecretionBrefeldin ABiochemistryNon-clathrin-coated BudsMedicine +7

Bidirectional Transport by Distinct Populations of COPI-Coated Vesicles

Lelio Orci, Mark A. Stamnes, Mariella Ravazzola, +4

Cell

Membrane TransportCopi-coated VesiclesTransport PhenomenaProtein TransportIntracellular Trafficking +3

Conversion of proinsulin to insulin occurs coordinately with acidification of maturing secretory vesicles.

Lelio Orci, Mariella Ravazzola, M Amherdt, +4

The Journal of Cell Biology

Proinsulin ConversionImmature Secretory VesiclesProtein SecretionBiochemistrySecretory Pathways +11

Sar1 promotes vesicle budding from the endoplasmic reticulum but not Golgi compartments.

Osamu Kuge, Christiane Dascher, Lelio Orci, +7

The Journal of Cell Biology

ImmunologyCytoskeletonViral Structural ProteinCellular PhysiologySecretory Pathway +18

Direct identification of prohormone conversion site in insulin-secreting cells

Lelio Orci, Mariella Ravazzola, M Amherdt, +3

Cell

BiochemistryNatural SciencesMedicineProhormone Conversion SiteEndocrinology +4

Stepwise assembly of functionally active transport vesicles

Joachim Ostermann, Lelio Orci, Katsuko Tani, +4

Cell

Membrane TransportCytoskeletonProtein TransportIntracellular TraffickingCellular Biochemistry +3

Coupling of Coat Assembly and Vesicle Budding to Packaging of Putative Cargo Receptors

Martina Bremser, Walter Nickel, Michael Schweikert, +6

Cell

Proteinlipid InteractionVesicle BuddingNatural SciencesCoat AssemblyMolecular Biology +6